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Practice parameter: Initiation of treatment for Parkinson's disease: An evidence-based review (Report of the Quality Standards Subcommittee of the American Academy of Neurology) JM Miyasaki, W Martin, O Sucherowsky, WJ Weiner, AE Lang Neurology 2002;58:11-17 The authors reviewed the literature concerning initiation of PD treatment from 1966 to 2000, selecting and analyzing results from prospective studies only to develop conclusions regarding efficacy of different treatment options. They conclude: --Selegiline has a mild symptomatic effect with no convincing evidence for either neuroprotection or increased mortality. --Levodopa, cabergoline, pramipexole, and ropinirole are effective for reducing motor and ADL disability, with levodopa being more effective than the other agents. --Cabergoline, pramipexole, and ropinirole reduce the risk of motor complications compared to levodopa, but are associated with a higher incidence of adverse events including hallucinations, somnolence, and edema. --The incidence of motor complications is not affected by the use of sustained-release versus immediate-release levodopa. Copyright 2001 WE MOVE Editor: Richard Robinson ([log in to unmask]) This service is provided free of charge to the Internet community, courtesy of WEMOVE.org. This document may be freely redistributed by email only in its unedited form. We encourage you to share it with your colleagues. Patient subscribers: Information presented in the above article(s) should not in any way be interpreted as medical advice. Please contact your physician if you have questions about the information presented by the E-MOVE news service or archives. It is not possible, nor is it appropriate for WE MOVE to respond directly to questions regarding medical management, including diagnosis and treatment. E-MOVE archives, plus information on subscribing, are available at http://www.wemove.org/emove. To unsubscribe, send an e-mail to [log in to unmask], with "unsubscribe e-move" in the message body. E-MOVE is a service of WE MOVE (Worldwide Education and Awareness for Movement Disorders) 204 West 84th Street New York, NY 10024 TEL 800-437-MOV2 TEL 212-875-8312 FAX 212-875-8389 http://www.wemove.org ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn