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The simplest explanation for this that I ever received (shaking vs. rigidity, stuttering vs. soft speech, etc....) is this: Envision the substantia nigra as a Supreme Pizza (with everything on it).......80% of that pizza is missing/damaged when we are diagnosed with PD. I may be missing all of the pepperoni and some of the cheese.......you may be missing most of the crust, but have all of the pepperoni left......someone else has only mushrooms and tomato sauce, etc. So we each have an individual version of the 20% of the substantia nigra that is working.......hence varying symptoms. Rita ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn