Hi Lynne: I really don't know that I can help you very much. Right now I am only taking Mirapex - 1 1/2 mgs. 3 timese a day. I haven't had any problems with it since I started taking it when it would make me tired. I think the next time I go to the neurologist he may put me on Sinemet . My tremor is gettting worse. I heead been taking Amantadine which iis supposed to help tremor so perhaps I should take it again. It had caused mottled skin on my legs. Sorry I can't be of more help. I've read where Mirapex taken with Sinemet seems to makes you able to lower the amount of Sinemet. Virginia ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn