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After 23 years of sinemet --it still works for me (along with permax, comtan and amanadine.) I take a combination of 21 pills per day. Its a lot of medication but that is what it takes to keep this old brain of mine clipping along. I have dyskinesias which are less on amantadine.I guess some things we have to accept. cheers carol gray ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn