new hope in the pipeline: http://pharmalicensing.com/news/headlines/1014332716_3c757d2c0813b Pharmlicensing 22 Feb. 2002 Titan Pharmaceuticals, Inc. has received a $2 million milestone payment from Schering AG, Titan's corporate partner for worldwide development, manufacture and commercialization of Spheramine, Titan's novel cell therapy for the treatment of Parkinson's disease. The milestone payment follows the recent successful completion of Titan's Phase I/II clinical study of Spheramine, and the decision to initiate larger, randomized clinical testing of Spheramine for the treatment of late-stage Parkinson's disease. Data from the recently completed 12-month study will be presented at medical conferences later this year. Spheramine is a novel cell therapy consisting of retinal pigment epithelial (RPE) cells adhered to microscopic carriers. RPE cells are normal, mature human cells that are implanted into the central nervous system to produce dopamine, a neurotransmitter that is deficient in the brains of Parkinson's disease patients. RPE cells are fully developed and differentiated cells, thereby potentially eliminating concerns associated with other approaches, such as use of embryonic neuronal cells or stem cells that can migrate and change after implantation. The elimination of the variables associated with post-implantation migration and differentiation is an important potential advantage for Spheramine. "Successful completion of the Phase I/II clinical study is an important milestone in the Spheramine product development program," stated Dr. Louis R. Bucalo, Chairman, President and CEO of Titan. "We are pleased with the continued progress of this development program," stated Dr. Joachim-Friedrich Kapp, Head of the Strategic Business Unit Specialized Therapeutics of Schering AG. "Preliminary results from the pilot clinical study are very encouraging, and we now look forward to further clinical testing of Spheramine." Titan Pharmaceuticals, Inc. is a biopharmaceutical company focused on the development and commercialization of novel treatments for central nervous system (CNS) disorders, cancer and other serious and life-threatening diseases. Stereotaxic Intrastriatal Implantation of Retinal Pigment Epithelial Cells Attached to Microcarriers in Advanced Parkinson disease (PD) Patients: Long Term Follow-Up Ray L. Watts, Cathy D. Raiser, Natividad P. Stover, Michael L. Cornfeldt, Alfred W. Schweikert, Richard C. Allen, Thyagarajan Subramanian, Roy A. E. Bakay Atlanta, GA; Somerville, NJ; Cleveland, OH; Chicago, IL OBJECTIVE: Evaluation of the safety and efficacy of unilateral stereotaxic implantation of cultured human retinal pigment epithelial (RPE) cells attached to microcarriers (Spheramine) in patients with advanced PD in an open label pilot study. BACKGROUND: Stereotaxic intrastriatal implantation of RPE cells attached to crosslinked gelatin microcarriers produces long term amelioration of parkinsonian motor behavioral deficits in rodent and non-human primate models of PD, with minimal host immune response. DESIGN/METHODS: Six patients with advanced PD (3 males; 3 females; mean age 52.2 years; mean duration of PD 10.2 years; mean Hoehn and Yahr stage "off" 3.75) were assessed at baseline and post-operatively using the modified CAPIT. Each patient underwent MRI-guided stereotaxic surgery during which a total of 325,000 RPE cells attached to microcarriers were implanted in 5 tracts, 5 mm apart in the post-commissural putamen contralateral to the most affected side. Immunosuppression was not used. RESULTS: All patients tolerated surgery well and no major adverse events occurred. Post-op MRI scans revealed accurate placement of tracts in all patients. Six patients have undergone monthly safety assessments and post-op CAPIT evaluations at 1, 3, 6, and 9 months, three at 12 months, and one at 15 months. The UPDRS Motor score in the practically defined "off" state (off all anti-parkinsonian medication for at least 12 hours); UPDRS-M(off) is the primary outcome measure. All patients have demonstrated some degree of improvement. At 6 and 9 months post-op, the mean UPDRS-M (off) score (n=6) improved to 35 (33%) and 30 (42%) respectively, from a pre-op baseline mean of 52. At 12 months post-op, the mean UPDRS-M(off) score (n=3) improved to 26 (48%) from a mean pre-op baseline value of 50. At 15 months post-op, the UPDRS-M (off) score (n=1) improved to 24 (44%) from a pre-op baseline value of 43. Mean 9-month improvements (n=6) in secondary outcome measures include the total UPDRS (40%), Timed Motor Tests (on, 16%; off, 35%), PDQ39 QOL (38%), and Schwab and England Physician Rated ADL (on, 11%; off, 34%). Bilateral improvement is observed in motor symptoms, with the greater effect seen contralateral to the implants. Moderate to marked reductions (37-53%) in time spent in the "off" state are currently seen in half the patients. Three of six patients currently have lower Dyskinesia Rating Scale scores than at baseline, while the scores of the other three are unchanged from baseline values. No "off-state" dyskinesias have been observed. CONCLUSIONS: This new cell implantation therapy appears to be safe and well tolerated out to 15 months post-implantation. Thus far efficacy evaluations in this open-label pilot study show promise. Further follow-up is ongoing. Supported By: Supported by a research grant from titan Pharmaceuticals, Inc. and NINDS, NIH (4R44 NS39211-02). 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