> Journal of Neurology Neurosurgery and Psychiatry 2002;72:546-548
> © 2002 Journal of Neurology Neurosurgery and Psychiatry
> <http://jnnp.bmjjournals.com/misc/terms.shtml>
> ------------------------------------------------------------------------
>
>
> SHORT REPORT
>
>
> Deep brain stimulation of the centre median-parafascicular complex
> in patients with movement disorders
>
> J K Krauss1,3, T Pohle 1, R Weigel3 and J-M Burgunder 2
>
> 1 Department of Neurosurgery, Inselspital, University of Berne, Berne,
> Switzerland
> 2 Department of Neurology, Inselspital, University of Berne
> 3 Department of Neurosurgery, University Hospital, Klinikum Mannheim,
> Mannheim, Germany
>
> Correspondence to:
> Professor Krauss, Department of Neurosurgery, University Hospital,
> Klinikum Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany;
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>
>
> ABSTRACT
>
> The centre median-parafascicular (CM-Pf) complex of the thalamusis
> considered to be a possible target for deep brain stimulation(DBS) in
> patients with movement disorders. In a prospectivestudy on the effect
> of CM-Pf DBS versus somatosensory thalamicDBS on chronic neuropathic
> pain, three of 12 patients had additionalmovement disorders. Bifocal
> quadripolar electrodes were implantedby computed tomography guided
> stereotactic surgery under local anaesthesia contralaterally to the
> side of the pain for teststimulation. Two of the three patients with
> movement disordershad permanent implantation of CM-Pf electrodes.
> During teststimulation of the left CM-Pf complex for several days, a
> 67year old woman received no benefit with respect to the
> neuropathicpain, but the choreoathetotic movements of her right foot
> ceased. As the pain syndrome was not improved, she decided not to
> havepermanent implantation. A 74 year old man with postzoster
> neuralgiaand allodynia enjoyed excellent relief from his pain with
> chronicCM-Pf DBS. In addition, improvement in the tremor at rest
> wasnoted. A 72 year old man had sustained reduction in his
> stumpdyskinesias. Further evaluation of the possible role of
> the"forgotten" central and medial thalamic nuclei in the treatmentof
> movement disorders may be warranted.
>
> ------------------------------------------------------------------------
>
> Keywords: deep brain stimulation; tremor; stump dyskinesia; thalamus;
> functional neurosurgery
>
> Abbreviations: DBS, deep brain stimulation; CM-Pf, centre
> median-parafascicular; VPL, ventroposterolateral; VPM, ventroposteromedial
>
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