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Lisa, I have been helping my wife Nancy for years with all of her meds. An abrupt change of agonists didn't seem to create major problems. The abrupt withdrawal of amantadine almost always caused her symptoms to worsen. If you can, restore the amantadine to your pre mirapex level and see if that doesn't improve things dramatically. Its really not a good idea to change more than one med at a time anyway because it is very difficult to determine which one is causing the problem. Be sure to let your doctor know exactly what you are doing, before you do it, if possible. Bob Martone [log in to unmask] http://www.samlink.com/~bmartone -----Original Message----- From: Parkinson's Information Exchange Network [mailto:[log in to unmask]]On Behalf Of Lisa Crumrine Sent: Saturday, April 06, 2002 10:23 AM To: [log in to unmask] Subject: Fw: HELP ----- Original Message ----- From: Lisa Crumrine To: Parkinson's Information Exchange Network Sent: Saturday, April 06, 2002 12:09 PM Subject: HELP I have abruptly changed meds, per my new neuro from .25 permax 5 x day to .125 mirapex 3 x day removed amantadine 4 x day and continued on sinemet 25/100 5 x day feeling semi ok at the moment but having a real hard time mostly. shaking /tremors and having a hard time moving my body at all, very stiff! any suggestions? new neuro is unreachable (it's saturday) and I dont really have anyone else to call, I am on an island in the Caribbean (VERY SMALL ISLAND) and don't have any one else to call or ask. Lisa in St John ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn