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Date: Sun, 14 Apr 2002 20:27:11 EDT
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Subject: Ahead of TIME: Human Guinea Pigs
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Ahead of TIME Newsletter<br>
Sunday, April 14, 2002<br><br>
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THIS WEEK'S COVER STORY
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<A HREF="http://newsletter.time.com/Y3RA060D6C424054D572" target="new">Human Guinea Pigs</A><br>
        About 20 million people were enrolled as research subjects last year-three times the number a decade ago, reports TIME's Michael Lemonick. Over the past three years, more than 60 institutions, including several of the world's most prestigious research centers, have been criticized by the U.S. government for failing to protect human subjects adequately. Federal records show that since 1999 at least four people who entered clinical trials in reasonably good health wound up dead-including two infamous cases at Johns Hopkins Medical Center and the University of Pennsylvania. Yet the very nature of human testing involves risk; nobody can tell in advance whether a new medicine carries unforeseen dangers. Make the rules protecting patients too lax, and subjects will suffer and even die needlessly. Make them too strict, and lifesaving medications won't make it out of the lab quickly enough to help the people who need them most, TIME reports.<P>

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HIGHLIGHTS FROM TIME MAGAZINE
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        <A HREF="http://newsletter.time.com/Y3RA060D6C4D4054D572" target="new">MIDDLE EAST: Who Will Blink First?</A><br>
        The U.S. is considering plans that would require the handover of land currently occupied by Israeli settlements in the Gaza Strip, and extend international recognition to an independent Palestinian state before a permanent peace is reached, a senior U.S. State Department official confirmed to TIME. The official said that Secretary of State Colin Powell has been pressing Israel, the Palestinians and the Arab states for their ideas about a deal. The ideas include the deployment of U.S. monitors and an international fund to rebuild Palestine, TIME's Massimo Calabresi and Romesh Ratnesar report. If these elements come together, officials say, they would probably lead to an international peace conference-involving Israeli, Palestinian and other Arab and European representatives‹that would try to map out the borders and capitol of the new state, TIME reports. Israeli army commanders last week proposed pumping nausea-inducing gas into Arafat's compound and the Church of the Nativity in Bethlehem to drive out the Palestinian fighters holed up there, Israeli sources told TIME. The idea was eventually rejected by Itzik Eitan, head of the Israeli Central Command, TIME reports.<p>


        <A HREF="http://newsletter.time.com/Y3RA060D6C4C4054D572" target="new">The Four Sticking Points</A><br>
        U.S. officials tell TIME that they are thinking about dangling an international offer of diplomatic recognition for Palestine to jump-start peace talks and boost American credibility with Arabs, TIME's Johanna McGeary reports. If it helps Colin Powell coax the Israelis and Palestinians back to negotiations, the dramatic gesture would be valuable. But it may not have any lasting effect on two sides so hate-soaked and at odds. McGeary explains the four chief obstacles to peace in the Middle East, including Palestine's borders, refugees, Jerusalem and the now deeper-than-ever hatred between both sides of the conflict.<p>


        <A HREF="http://newsletter.time.com/Y3RA060D6C4F4054D572" target="new">MOVIES: Girls Just Wanna Have Guns</A><br>
        This month gave a beam of hope to those desperate for gender equality on screen, writes TIME¹s Richard Corliss. The two top films for the April 5-7 weekend were thrillers starring women: David Fincher's Panic Room, with Jodie Foster besieged by three burglars, and Carl Franklin's High Crimes, in which lawyer Ashley Judd defends her enigmatic husband in a high-stakes court-martial. This week in Murder by Numbers, Sandra Bullock plays a cop on a homicide investigation that points to two brilliant teenagers. And on Memorial Day weekend, Jennifer Lopez provides a Star Wars alternative with the spousal revenge drama Enough, TIME reports.<p>


        <A HREF="http://newsletter.time.com/Y3RA060D6C4E4054D572" target="new">PERSONAL TIME: The Day The Shots Ran Out</A><br>
        The U.S. is running out of vaccines needed to immunize infants, TIME's Christine Gorman reports. The biggest shortfalls: chicken-pox vaccine, various tetanus vaccines and the so-called pneumococcal conjugate vaccine. Here's another paradox: the U.S. government is about to spend $850 million to make sure there's enough smallpox vaccine to protect every man, woman and child against the theoretical risk of a bioterrorist attack. Yet at the same time it's having trouble protecting kids from the clear and present danger of tetanus and meningitis. We're not on the verge of a chicken-pox epidemic, but the longer the shortages persist, the greater the risk. "All you need is one case to get you into trouble," Dr. James McCord of the Children's Hospitals and Clinics in St. Paul/Minneapolis, Minn. tells TIME.<p>
    For more, see <a href="http://newsletter.time.com/Y3RA060D6C494054D572">this week's table of contents</a>.
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WEB EXCLUSIVES

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--&gt; NATION
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<A HREF="http://newsletter.time.com/Y3RA060D6C484054D572">The FBI Puts Suspects Online</A><br>
    Looking to share crucial information about suspects with local law enforcement, the feds incorporate their list into a national crime database<P>

--&gt; WORLD
<br><br>
<A HREF="http://newsletter.time.com/Y3RA060D6C4B4054D572">Who Will Blink First?</A><br>
    Colin Powell lays out the U.S. strategy for peace -- and a Palestinian state. But the hatred is threatening to make both impossible<P>

--&gt; ARTS SAMPLER
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<A HREF="http://newsletter.time.com/Y3RA060D6C4A4054D572">OZZY Knows Best</A><br>
    'The Osbournes' has a bleeping thing or two to teach the networks about comedy -- and decorating with crucifixes<P>

--&gt; SPECIALS
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<A HREF="http://newsletter.time.com/Y3RA060D6C754054D572">Person of the Week</A><br>
    Colin Powell<P>

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