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Lisa, I hope things are improving, but if not here is what I found out for you via Doc. Abe Lieberman today. We attended the 15 anniversary meeting today in San Juan where he was the special quest speaker. I spoke with him after the meeting and he suggested revving up the Mirepex, a little faster than normal, since your body was already accustomed to the agonist Permax you had been taking. What your experiencing is the "change over" which may not be drastic for everyone to make , but in reality, is usually some what traumatic. He said it will just take some time to make the adjustment. He agreed that your probably under, not over, medicated. As you titillate (increase) up on your Mirapex things should begin to smooth out. You might try your original 5 Sinemet with a .025mg Mirapex each time and stay tuned to what happens. As you encrease your mgs. of Mirapex choose a more relaxed time in your meds schedule and drop a Sinemet from your daily total. If this takes too big of toll bring back the Sinemet until you get to a higher level of Mirapex and then try again. If the Mirapex is going to work for you it should eventually take away some of the Sinemet need. My personal experience is that I carry the extra Sinemet with me and, as most of us realise that there is almost no two days alike, I take it if I need it, but I'm getting along pretty good now that I've reached a higher level of Mirapex. I'll give you a land line maņana. I'm really sorry the change over is going this way for you. the gringo pastor From: "Lisa Crumrine" <[log in to unmask]> To: <[log in to unmask]> Sent: Saturday, April 06, 2002 3:20 PM Subject: Re: help re: fw Help > saw new neuro on thurs, started new drugs on Friday. asked if it was going to be ok to change from permax to mirapex that dramatically , he said no problem and that I should be feeling better right away. I cant just go back to the neuro on Monday because he is a 1/2 a days journey by boat and plane and car...I suppose I could just go back to my old med doses on the old drugs but that is going to mess me up also. I am 44 yrs old dx '93 pd 9 yrs > > been having probs with the old drugs for awhile (that is why I am switching > ( sinemet 5 x 25/100 5 x permax .25 3 x symetryl) see previous post "help > thanks for any feedback > Lisa > st john usvi > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn