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Re-Post? - Yogurt bacteria may help migraine sufferers, researchers say

MILAN, Italy (April 26, 2002 3:53 p.m. EDT) - Some headaches may be linked
to infection with a common bug and daily doses of friendly bacteria could
ward them off, preliminary research suggests.

A study presented Friday at an infectious diseases conference found that
about eighteen percent of chronic migraine sufferers were infected with the
stomach bug helicobacter pylori and antibiotics appeared to clear the
headaches.

Adding the friendly bacteria Lactobacillus seemed to work even better,
leaving most people migraine-free for a year and lessening the intensity
and frequency of recurring headaches in the others, the lead researcher said.

Experts were cautiously receptive to the idea but said the findings were
too tentative to draw any firm conclusions.

Helicobacter pylori, the bug that causes gut ulcers, has recently been
linked to a growing list of diseases, including heart disease, autoimmune
diseases and skin conditions.

In the study, Italian scientists divided one hundred and thirty patients
who had migraines and were infected with helicobacter pylori into two groups.

One group was given a three-week course of antibiotics and the other got
the three weeks of antibiotics plus Lactobacillus, a friendly bacteria, or
probiotic, found in yogurt and other dairy products.

The probiotic group took three Lactobacillus doses a day for three months,
then dropped their intake to one dose a day for the next nine months.

One month after starting treatment, both groups were similar in terms of
headache symptoms and bacteria colonization.

However, after one year, significant differences were found, said the
study's leader, Dr. Maria Gismondo, head of the clinical microbiology
laboratory at the University of Milan.

"We found that eradication of headache and bacteria was more significant in
the group treated with antibiotics and Lactobacillus, and relapse in the
people who took Lactobacillus was very low, but not in the people not
getting Lactobacillus therapy," she said.

At the end of the year, fifty percent of the people who got the antibiotics
alone were still getting migraines. That compared with twenty percent in
the group who took the probiotics for a year.

Headaches in the probiotic group occurred less often, were milder and went
away more quickly than they did in the antibiotics group.

The infection findings were similar. After a year, the bacteria were forty
percent fewer in the group who took antibiotics and seventy percent fewer
in the group getting the combination treatment.

"Our understanding is that Lactobacillus could be used, not to cure or
eradicate H.pylori, because it is not an antibiotic, but to prevent relapse
of H.pylori infection and headache."

Headache expert Dr. Peter Goadsby, professor of clinical neurology at the
Institute of Neurology and the National Hospital for Neurology and
Neurosurgery in London, reserved judgment.

He said the fact that the study did not involve a group getting dummy pills
makes the findings less reliable.

The study cannot rule out the "placebo effect," whereby people get better
purely because they believe the pills they are taking are working, not
because the pills are actually doing anything.

Goadsby said the placebo effect can account for up to thirty percent of the
improvement noted in studies like this one. Testing the effectiveness of
treatment by giving some people the medicine and some fake pills overcomes
that problem.

"There may be something in this ... but show me the money. I'd like to see
a placebo-controlled trial," Goadsby said.

By EMMA ROSS, AP Medical Writer
Copyright 2001 Nando Media
Copyright 2002 AP Online
http://www.nando.net/healthscience/v-text/story/381517p-3043541c.html

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