FROM: The Boston Globe April 22, 2002, Monday ,THIRD EDITION HEADLINE: COALITION BATTLES BILL TO BAN CLONING CASE FOR RESEARCH BROUGHT TO SENATE BYLINE: By Mary Leonard, Globe Staff WASHINGTON - Major universities, biotechnology companies, and scientists are making a fervent case to Congress against pending legislation that would ban human cloning for any purpose and outlaw a basic type of biomedical research. The proposed ban on human cloning, whether for reproduction or research, passed the Republican-controlled House last summer by a vote of 265-162 and is expected to be debated by the end of May in the Democratic-controlled Senate, where the vote appears too close to call. President Bush recently gave the bill a boost when he forcefully endorsed it, saying all human cloning is immoral and unethical. Reproductive cloning - creating a genetic copy of a human being for reproductive purposes - has few defenders. Scientists are focusing on therapeutic cloning, in which embryonic material is used to produce cell lines that would be useful in the treatment of diseases. The research lobby has argued that a ban on therapeutic cloning would create a climate of fear in laboratories, have a chilling effect on medical breakthroughs, and force pioneering research involving stem cells to relocate overseas, taking with it potential commerce based on treatments that might be developed. Harvard University played a leading role in blocking a similar ban in 1998, and its new president, Lawrence H. Summers, recently sent a letter to senators, saying he was deeply concerned that the new legislation would block potentially life-saving research. Summers recommended that Congress ban reproductive cloning but allow therapeutic cloning research. Executives from 150 biotechnology firms from Massachusetts and across the nation plan to meet in Washington Wednesday with senators and their staff members to lobby against the proposed ban. "Our members understand that it would be setting a miserable precedent to criminalize a promising and responsible area of scholarship and make areas of research vulnerable to ideological or political attack," said Carl Feldbaum, president of the Biotechnology Industry Organization, the association that organized this week's lobbying campaign. The legislation would impose fines of $1 million and prison terms of up to 10 years on scientists who clone human embryos. Congress never has approved criminal penalties for any biomedical research, although 30 years ago lawmakers considered banning DNA experiments. Scientists put a temporary voluntary moratorium on the research instead. The most common form of human cloning involves collecting genetic material, such as cells, from an individual and transferring it into an unfertilized egg to create an embryo. If the embryo were implanted in a womb, the embryo might in theory develop into a fetus with the same genetic material as the cell donor. Most scientists argue that progress in stem-cell research - aimed at diseases such as Parkinson's, Alzheimer's, and diabetes - depends on allowing the development of technologies to clone human embryos, from which stem cells can be derived. Stem cells are undifferentiated; that is, they can theoretically be induced to develop into cells with a specific function, such as the cells that produce insulin in the body. Cloning, an issue for conservatives for several years, took on more urgency after Advanced Cell Technology of Worcester announced in November that it had created the first cloned human embryos. These contained no more than six cells, although ACT had attempted to produce embryos of at least 100 cells from which it might extract stem cells. ACT is still the only company that has reported human-embryo cloning. Its goal, to obtain and stimulate the stem cells to grow into healthy tissue for patients with diseases or damaged organs, could not be achieved under a research ban, said Dr. Robert Lanza, ACT's chief medical officer. "It would put us out of business, and that would be sad," Lanza said. "But it's not a matter of whether we do or do not survive. There is an urgent health crisis, and if we can't contribute to the coming revolution in medicine, that would be a shame." Not all biotech executives oppose a total ban. Thomas Dooley, who heads IntegriDerm, Inc. in Huntsville, Ala., argued that scientists do not need cloned embryos because adult stem cells are available. What has energized universities and entrepreneurs, he said, is the economic threat that a research ban would represent. "Morality should be elevated above the profit motive, research grants, and private-sector money," said Dooley, who resigned as president of the Alabama affiliate of the Biotechnology Industry Organization after it opposed a ban on research involving human cloning. The immediate economic impact of a research-cloning ban would be small, but it could have consequences in the future, said Janice Bourque, president of the Massachusetts Biotechnology Council, which represents more than 250 companies. "The biotech industry is a major economic driver in the state, and not participating in this health-related research could mean losing out on billions of dollars," she said. Universities and scientific organizations such as the American Association for the Advancement of Science, the American Society for Cell Biology, and the Juvenile Diabetes Research Foundation, have joined the lobbying campaign, calling the proposed ban a threat to academic freedom and basic research. Earlier this month, 40 Nobel laureates signed a letter that said criminalizing research would send a signal that "unfettered and responsible scientific investigation is not welcome in the United States." Jane Corlette, Harvard's associate vice president for government affairs, said, "This could have a chilling effect on future medical research because young scientists won't risk going to jail, incurring a huge fine, or being shut down." Lobbying has focused on the Senate, where 20 members are believed to be undecided on the issue. Senator Sam Brownback, a Kansas Republican who is the chief sponsor of the bill, said all forms of cloning "are wrong, period. I do not believe we should create life just to destroy it, but that is exactly what is being proposed by those who would allow cloning in limited circumstances." Senator Edward M. Kennedy is preparing a competing bill that would make "the abusive medical practice" of reproductive cloning illegal but permit research-related cloning. Senator John F. Kerry supports Kennedy's bill, a Kerry aide said. Rudolf Jaenisch, an MIT biologist and pioneer in mouse cloning at the Whitehead Institute for Biomedical Research in Cambridge, said criminalizing research cloning would be "absolutely disastrous" because it would drive the technology overseas and underground, outside federal regulation and university oversight. Government regulations restrict medical experiments on human and animal subjects, and researchers who obtain federal grants can be fined or sanctioned by agencies such as the US Food and Drug Administration and the National Institutes of Health. Under the Atomic Energy Act, scientists who use nuclear materials without a federal license are subject to criminal prosecution by the Justice Department. Mary Leonard can be reached by e-mail at [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn