 |
 |
Cathy, my meds have recently been changed in that Comtan (entacapone, a COMT Inhibitor) has been added. I had ben taking Sinemet CR 50/200 and Requip 2 mg. together at four hour intervals - typically 7, 11, 3, and 7. I am just starting a new regimen, consisting of Sinemet CR 25/100, Comtan 200 mg, and Requip 2 mg. at 11, 3, and 7, but at 7 AM I take a Sinemet CR 50/200, broken into two halves. The rationale behind this is that it should give me a faster start than an unbroken 50/200, faster than two 25/100's, and, oh yes, I have an inventory of the 50/200's. Yes, I seem to have the same drowsy effect around noon, but that is not the point of this posting. While my change is recent and the results very much subjective, it appears that I can cut my Sinemet usage by 38%. Comtan therapy works only when coupled with Sinemet. Had I not been taking a relatively large dose of Sinemet, it might have been possible to achieve good results by cutting back on the agonist - in our case, Cathy, Requip instead. In other words, it might have been suitable for me to have been put on COMT-inhibitor therapy, keeping Sinemet the same, while reducing the amount of Requip. I am not a doctor, and I cannot assure you that this would help - or even work. With this designer disease, Parkinson's, it's hard to predict what will work and what will not. At least this may be another avenue to explore. Art At 10:28 AM 5/2/02 , Cathy ([log in to unmask]) wrote: > I have been observing the interaction of list members and decided to take >the plunge and introduce myself. I was diagnosed with PD a year ago at age >53. I am taking Requip 3 times daily and Selegiline 2 times a day. I am >also and RN. I was wondering if any one else who takes these drugs has an >overwhelming urge to take a nap about an hour after taking them. The drugs >seem to be helping my other symptoms (restless leg syndrome, rigidity and >slowness) Interestingly, I only notice the fatigue after taking the >morning dose and not after the later doses. > Thanks, and forgive me if this topic has been >previously addressed. I'll quit now as I need a nap! Cathy RN > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn