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Hi David - Mom (Age 68 dx 42 sx 40) has really bad side effects from all agonists and she's gotten very sensitive to "overdoses" of sinemet, so she takes one 25/100 sinement at 5:00 am, then one half of a 25/100 sinemet every hour from 6:00 am to 6:00 pm. At 7:00 pm she takes requip (this seems to keep the "wearing off" dyskinesias away) and seroquel (for requip's side effects). Hope this helps. - Doug ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn