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I don't know if they are "significant signs... I was diagnosed at 39, five years ago. My first inkling was a sore back, "robotic walking," stiff movement of the upper torso, minimum arm swing and the good old "parkinson mask." Tremor and on/off feelings came later. Hope this helps with your concern. Scott Burnett ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn