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The duration of a dose of Sinemet varies widely from individual to individual, and also with the stage of the disease. IN GENERAL, regular Sinemet lasts from 2 to 4 hours, while extended release forms may last 4 to 6 hours. However, PWPs early in their disease may find that a single dose may be effective for considerably more time than that - allowing three times daily administration of even the regular form to suffice. As the disease progresses, it appears that the duration of action shortens. Sometimes increasing the size of a dose of Sinemet is enough to make it last longer. More often, a switch to the ER or CR formulation, or adding COMTAN or Deprenyl, adding an agonist, or switching to an agonist, are all strategies that help deal with the shorter duration of each dose. Keeping a diary with a schedule of "on-time" and "off time," as well as the times of dosing, is very helpful to the neurologist when trying to decide which strategy to recommend. Jorge Romero, MD ----- Original Message ----- From: "David Moreland" <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, May 12, 2002 2:42 PM Subject: frequency of sinemet doses > I take sinemet 50/200 CR and it works gfor me to take them every 4 houres > saeting > at 6:00 AM. It is my understanding that the standard 25/100 will last about > two hours or with Comtan they might last three hours. Now this is hiw they > work for me. i have tried just about every combination of PD medication and > this is what works most consistently for me. I have only been a Parkie for > 15 years. > > At 02:20 PM 5/12/2002 -0500, you wrote: > >hi would someone tell me please how you space your sinimet doses?? four > >hours apart, six hours? or what? i know it works differently for every > >individual, but i would just like to get a general idea of what works for > >some of you please. my mother was taking hers seven or eight hours apart > >and of that is not working. thanks a lot paula ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn