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I guess a main question i have is, how important is the last dose of sinimet before one goes to bed? in other words, if someone takes a dose at like 8 pm and then does not go to bed until 11 pm, they have the entire night without any more doses, but as soon as they get up, they take another dose. ----- Original Message ----- From: "Jorge Romero MD" <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, May 12, 2002 3:27 PM Subject: Re: frequency of sinemet doses > The duration of a dose of Sinemet varies widely from individual to > individual, and also with the stage of the disease. > > IN GENERAL, regular Sinemet lasts from 2 to 4 hours, while extended release > forms may last 4 to 6 hours. > > However, PWPs early in their disease may find that a single dose may be > effective for considerably more time than that - allowing three times daily > administration of even the regular form to suffice. > > As the disease progresses, it appears that the duration of action shortens. > Sometimes increasing the size of a dose of Sinemet is enough to make it last > longer. More often, a switch to the ER or CR formulation, or adding COMTAN > or Deprenyl, adding an agonist, or switching to an agonist, are all > strategies that help deal with the shorter duration of each dose. > > Keeping a diary with a schedule of "on-time" and "off time," as well as the > times of dosing, is very helpful to the neurologist when trying to decide > which strategy to recommend. > > Jorge Romero, MD > > ----- Original Message ----- > From: "David Moreland" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Sunday, May 12, 2002 2:42 PM > Subject: frequency of sinemet doses > > > > I take sinemet 50/200 CR and it works gfor me to take them every 4 houres > > saeting > > at 6:00 AM. It is my understanding that the standard 25/100 will last > about > > two hours or with Comtan they might last three hours. Now this is hiw they > > work for me. i have tried just about every combination of PD medication > and > > this is what works most consistently for me. I have only been a Parkie for > > 15 years. > > > > At 02:20 PM 5/12/2002 -0500, you wrote: > > >hi would someone tell me please how you space your sinimet doses?? four > > >hours apart, six hours? or what? i know it works differently for every > > >individual, but i would just like to get a general idea of what works for > > >some of you please. my mother was taking hers seven or eight hours apart > > >and of that is not working. thanks a lot paula > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn