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The evening and bedtime doses of Sinemet are often helpful. Some PWP find that unless they take a bedtime dose, they are unable fully to relax for sleeping. Invariably, the effect is worn out by morning, if you sleep on the average six to eight hours. I usually advise taking the AM Sinemet "before you kiss your spouse" or brush your teeth: i.e first thing in the morning. Some PWP like to take a regular Sinemet, since it works faster. Seek the advise of your neurologist if you are having this type of problem. Jorge Romero, MD ----- Original Message ----- From: "patandpaula" <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, May 12, 2002 4:27 PM Subject: Re: frequency of sinemet doses > I guess a main question i have is, how important is the last dose of sinimet > before one goes to bed? in other words, if someone takes a dose at like 8 > pm and then does not go to bed until 11 pm, they have the entire night > without any more doses, but as soon as they get up, they take another dose. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn