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Paula I require Dosages (50/200) sinemet every 4 hrs- 8:00AM, 12:00AM, 4:00PM, 8:00PM, 12:00PM, 4:00AM Each dosage is complimented with 500 mg of Comtan to make sinemet last the full 4 hrs. Note: Sinemet CR 50/200 did not work for me at midnite hence the wakeup and regular dosage at 4AM. I need both the midnite and 4 am full dosage or I am not mobile for 1 1/2 hrs upon wakeup. For me this is the only combo so far that allows me to get up in AM at any time without being to rigid to move. Only her neurologist should be making any changes. If you don't feel that he is meeting your mothers quality of life needs then get her to another mds neuro. Don 53/4 On Sunday, May 12, 2002, at 06:29 PM, patandpaula wrote: >snip > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn