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dave, I have had PD for 25 years and every three hours I take 2 ssinemet 25/100. I also take comtan with each dose. I also take permax three times daily and amantadine twice daily. carol gray houstom, tx. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn