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Commenting on Debra Sutton's remarks: > Raj, > My opinion would be to take the sinemet. There is some debate as to whether > Mirapex and Requip might slow down the progression of PD but right now > nothing has been proven and the truth is, the side effects of Requip and > Mirapex are rotten!! Actually if you lived in Europe or Canada, you would > not be allowed to legally drive if you were prescribed either of these drugs > due to the incidence of somnolence. The side effects of the Sinemet (at > least for me) have been pretty mild and it works much better than the > agonists. > Debra Debra: very interesting, the wide range of responses to medications. 1. I am unaware that I have ever had side effects from Mirapex, certainly not negative ones, I thought. However, you have raised doubt in my mind: sometimes I do get severe muscle pain, immobilizing me for 2-3 days at a time. I wonder now if this was caused by Mirapex. Thanks for the alert, I will try to isolate the Mirapex effect from the Parkinson's next time it happens. Thanks! 2. I sometimes take Mirapex in the afternoon without Sinemet CR and it seems to be effective if I am physically inactive, not exercising. 3. Sinemet has never affected my state of alertness, that I can tell. Not taking it in time, I get 'down' or 'off'; I get confused, bothered by complexity. Also I sometimes can't say the precisely correct word for something, 'close, but no cigar'. Dan W. Scott ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn