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David - I take sinemet 25/100 CR (generic) 1. With Mirapex 0.25 mg first thing in morning, usually at 4:30 to 5 am I exercise most days in a pool, for about 2-1/2 hours five days/week, e.g. from 6:30 am to 9 am, about 10 minutes of which is strenuous aerobic and 30 minutes or more is just loafing, or -- most often -- is very light-duty, but still purposeful, arm and leg waving/training. How long do I 'loaf'? well, no rule; it depends on how I feel! 2. With Mirapex 0.25 about 3 pm. 3. With Mirapex 0.5 last thing, about 12:30 am. Yes, I need little sleep! This schedule seems to work for me (of course, not ALWAYS), but I would quite welcome comment. I AM EXCEEDINGLY CAREFUL always to take sinemet only when my stomach has been 'empty' for 1-1/2 hour and remains 'empty' for 1-1/2 hours thereafter. In this instance 'empty' means 'empty of protein', so I allow myself orange juice, grapes, strawberries and so forth during the 3-hour interval, as I assume that the five (or whatever) neutralizing amino acids will be absent from these foods, and of course, from water. I have found that if I cut the period to 3/4 or 1 hour and eat something with protein, such as milk or yogurt, the Sinemet may not be not very effective. If I begin to go down, I sometimes take an extra 0.25 mg Mirapex, ad lib; of course this takes a while to kick in. Dan W. Scott [log in to unmask] Diabetic II, PWP 18 years, 71 years old. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn