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Prog Clin Biol Res 1989;317:1235-46 Related Articles, Books, LinkOut

Double-blind study with phosphatidylserine (PS) in parkinsonian patients
with senile dementia of Alzheimer's type (SDAT).
Funfgeld EW, Baggen M, Nedwidek P, Richstein B, Mistlberger G.
Med. Faculty University, Marburg, FRG.
Experimental and clinical studies showed that Phosphatidylserine--special
preparation from cow's brain by FIDIA, Abano Terme, Italy--is able to
influence cerebral changes contributed to the symptoms of senile dementia of
Alzheimer's type. The application of the computerized EEG method DYNAMIC
BRAIN MAPPING (HZI Research Center, Tarrytown, New York) is able to proof
the therapeutic effect of Phosphatidylserine: the acceleration of a slowed
EEG in Parkinsonian patients with SDAT. These reactions were seen previous
to the favourable clinical influence documented by the Sandoz Clinical
Assessment Geriatric Scale (SCAG), which showed a significant amelioration
in anxiety, motivation and affectivity by the verum drug. Acute and
long-term CEEG results--till 18 months--showed that the so-called Theta
anteriorisation can be reduced or even abolished; this is replaced by Alpha
waves. Even in preclinical cerebral changes this method open the possibility
to show incipient alterations of the brain metabolism. Preliminary
therapeutic results leads to this and not prooven hypothesis that prevention
or retardation of cerebral ageing might be possible.

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