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Bruce ger The negative reaction to the caffeine was an increased tremor, which lasted for 2 or 3 hours. The 150 mg, that is 3 tablets of 50 mg during the day, was not a prescribed dose, it was an arbitrary starting point. My husband is a Chartered Engineer engaged in research, and meetings can be very tiring. Caffeine, as well as being said to be neuroprotective, is a stimulant and it was certainly helpful. ----- We shall review the dose and try it again, but probably on an ad hoc basis. Thank you for the information on the nicotine patch. I have written to Abbot Laboratories who are apparently doing some research on a nicotine-like substance for Parkinson's but I have not as yet received a reply. If I get one I will post it on the List. There is some information too on a nicotine drink, reference appended, but whether this would help or not I do not know. The patch delivers a constant dose. Maybe an add hoc dose would be more effective. I believe it is only thought to be useful in early to moderate Parkinson's. The statistics on smokers' reduced susceptability, however, are impressive and nicotine is an area we shall continue to research. "SMOKERS MAY BE ABLE TO DRINK A FIX A US firm has developed a product that will allow nicotine addicts to relieve some of their cravings in non-smoking areas. Nico Water comes with 2 or 4 milligrams of nicotine, but is intended as a supplement rather than as a replacement. The US Food... http://www.netdoctor.co.uk/news/index.asp?y=2002&m=5&d=23#id79525" gorhemmynnadow a'n gwella (with all good wishes) Julie Original Message ----- From: "Bruce Anderson" <[log in to unmask]> To: <[log in to unmask]> Sent: Thursday, May 23, 2002 9:03 AM Subject: caffeine n nicotine > Would you mind sharing with us what was the negative reaction to the > caffeine? And was 150 mg per day the prescribed dosage? Did your husband > build up to that amount? > > I tried the nicotine patch last summer at the suggestion of my doc, an MDS, > n it didn't do a thing for me [either positive or negative]. I used the > strongest kit they sold. My neighbor - who is a good RN - was against it - > she said it causes heart attacks. > > Thank you in advance for the info on the caffeine. > BBA > > ----- Original Message ----- > From: "winddam" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Monday, May 20, 2002 2:07 PM > Subject: Re: IHT: Hints of a Parkinson's 'cluster' > > > > Janet ger > > > > We are especially interested in the effects of caffeine on Parkinsons. My > > husband tried 150 mg of caffeine a day for 6 days and the effect was > > positive and noticeable. The tremor ceased or reduced, he was alert and > > able to work normally without fatigue. Unfortunately a reaction set in on > > the 6th day. > > > > I am also trying to get more information on studies with the nicotine > patch. > > I know that studies in Germany were negative or inconclusive, but this was > a > > small sample with advanced disease and the patch is claimed to be most > > effective in early mild symptoms. Other studies have apparently been > > carried out. > > > > Does anybody have any information, either about caffeine or nicotine? > > > > dhiso > > > > Julie > > > > > > ----- Original Message ----- > > From: "janet paterson" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Monday, May 20, 2002 11:29 AM > > Subject: IHT: Hints of a Parkinson's 'cluster' > > > > > > > Hints of a Parkinson's 'cluster' > > > > > > Thursday, May 16, 2002 - NEW YORK - 2 years ago, after giving up his > > > television series "Spin City," Michael J. Fox created a medical research > > > foundation that already is renowned for its fast-paced disbursements to > > > scientists. > > > > > > Since April of last year, the Michael J. Fox Foundation for Parkinson's > > > Research has given out nearly $17 million to help finance 57 studies. > > > > > > The foundation supports studies covering everything from gene therapy to > > > the effects of caffeine on Parkinson's disease. > > > > > > It has recently dedicated $4.4 million to developing stem cell lines > that > > > could be implanted in the brains of Parkinson's patients to replace the > > > dopamine-producing cells they have lost. > > > > > > It is about to underwrite strategies for reducing dyskinesia, the > > > involuntary movements that are side effects of taking L-dopa, the drug > > used > > > most often to quell the tremors and rigidity of Parkinson's disease. > > > > > > Fox's celebrity can do more than raise money. It may also help open an > > > avenue of research that scientists have long wanted to explore. > > > > > > Fox, it turns out, was one of 4 people who worked on a production crew > at > > a > > > television studio in Vancouver in the late 1970s and developed > Parkinson's > > > disease. Given that only 125 people worked on the crew in those years - > > > including actors, directors, writers, production people and > technicians - > > > the number of cases seems extraordinary. > > > > > > Typically, Parkinson's disease afflicts 1 in 300 people. In people as > > young > > > as Fox, 30 when the disease was diagnosed in 1991, the illness is much > > rarer. > > > > > > Fewer than 5 percent of Parkinson's patients develop symptoms before age > > > 50, said Caroline Tanner of the Parkinson's Institute. So the situation > is > > > even more unusual because the Vancouver cluster includes Fox and a woman > > > who learned she had Parkinson's at age 38. > > > > > > The 4 people worked together from 1976 to 1980, when it is possible that > > > the disease began in all of them. > > > > > > Parkinson's progresses gradually, taking 5 to 10 years from the time it > > > starts to the appearance of the first symptoms - usually, rigidity in an > > > arm or leg or tremor in a hand. > > > > > > Donald Calne, director of the neurodegenerative disorders center at the > > > University of British Columbia, estimates that the odds of the four > cases > > > occurring at the same time in such a small group of people are less than > 1 > > > in 1,000. > > > > > > He and other scientists say the cluster warrants investigation. > > > > > > "I would say that would certainly show up on my radar screen," said > > William > > > Langston, director of the Parkinson's Institute in Sunnyvale, > California, > > > and chief scientific adviser to the Fox Foundation. "I would definitely > > > want to look further." > > > > > > Clusters of Parkinson's cases occur from time to time, when, for > example, > > a > > > number of people in a neighborhood or small town develop the disease. > But > > > they often go unnoticed or are ignored because scientists lack the time > > and > > > money to look into them. > > > > > > In this case, the publicity surrounding Fox's admission that he had > > > Parkinson's, nearly three and half years ago, drew the cases into the > > > spotlight. > > > > > > Don Williams, who directed Fox in two Canadian situation comedies > > beginning > > > when the actor was 16, also has Parkinson's. He learned of his illness 9 > > > years ago, when he was 55. Sally Gardner, whose Parkinson's was > diagnosed > > > when she was 38, in 1984, had been a script supervisor in the late > 1970s, > > > and had worked with Fox and Williams. The fourth member of the cluster > is > > a > > > cameraman who has kept his identity secret; his diagnosis came at age > 54. > > > > > > Could something at the television studio have caused the disease in all > 4 > > > people? Calne, Langston and other experts believe it could have. Perhaps > > > something they breathed or ate or drank - a toxin, perhaps, or an > > > infectious agent - set the disease process in motion. > > > > > > "If this is a genuine cluster and not a statistical fluke," said Oliver > > > Sacks, a neurologist and writer, "it would certainly suggest an > > > environmental agent at work." > > > > > > The mystery is especially compelling because scientists do not know what > > > causes most cases of Parkinson's. Most believe that both genetic and > > > environmental factors are at work. > > > > > > "We often say that maybe people have some gene that predisposes them to > be > > > susceptible to any number of things in the environment," said William > > > Weiner, chairman of neurology department at the University of Maryland > > > School of Medicine. "But that's probably just another way of saying we > > > don't know the cause." > > > > > > The disease occurs when cells in the substantia nigra, a darkly > pigmented > > > part of the midbrain, about half the size of an adult index fingernail, > > > start to die off. These cells produce dopamine, a chemical messenger > that > > > is essential for normal muscle movement. > > > > > > The cell death occurs gradually, and that is why Parkinson's can go > > > unnoticed for so long. Once dopamine production declines by about 80 > > > percent, the patient begins to experience the 4 classic symptoms: > tremor, > > > stiffness, slow movement and problems with walking, posture and balance. > > > > > > In some cases, the cell death is set off by genetic mutations. > Scientists > > > have identified two genes that are involved in Parkinson's and have > > > pinpointed the locations of 4 others. > > > > > > But Parkinson's does not seem to be primarily a genetic disorder. It > runs > > > in the families of only about 10 percent to 15 percent of patients, > Tanner > > > of the Parkinson's Institute said. A large study she conducted indicated > > > that the identical twins of Parkinson's patients are no more likely to > > have > > > the disease than fraternal twins - a sign that the disease is not > largely > > > genetic. > > > > > > Environmental agents have also been known to create symptoms. In the era > > of > > > World War I, for example, some people who had contracted the virus that > > > causes sleeping sickness later developed what came to be known as > > > post-encephalitic parkinsonism, a particularly severe disorder that left > > > people in trancelike states. > > > > > > It is possible that a virus could also have been involved in the > so-called > > > Fox cluster. "It is important to look for infectious as well as toxic > > > agents," Sacks said. > > > > > > Mary Duenwald The New York Times > > > Copyright 2002 The International Herald Tribune > > > http://www.iht.com/articles/57830.htm > > > > > > janet paterson: an akinetic rigid subtype, albeit perky, parky > > > pd: 55/41/37 cd: 55/44/43 tel: 613 256 8340 email: [log in to unmask] > > > smail: 375 Country Street, Almonte, Ontario, Canada, K0A 1A0 > > > a new voice: http://www.geocities.com/janet313/ > > > > > > ---------------------------------------------------------------------- > > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > > In the body of the message put: signoff parkinsn > > > > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn