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In a message dated 6/2/2002 3:58:10 AM, [log in to unmask] writes: << "adds to the debate over whether the current use of dopamine in the treatment of Parkinson's could make things worse in the long run," >> Rhys, My neuro said there is some evidence that dopamine, while effective initially, in the long run may have some destructive effects. I don't know the specifics but, like you, would like to know more. I found it interesting to read fairly recently about the patient who received an experimental treatment and, a year later, still showed significant amelioration of symptoms even though his dopamine levels, which had risen with treatment, had declined to their original levels. This suggests to me that dopamine depletion is only part of a complex interaction and focusing on dopamine alone is not going to get us where we need to go. Regards, Kathleen ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn