Hi! I remember reading sometime ago which amounted to someting like this: It is known that dopamine producing cells are stimulated to produce more dopamine-lioke substances from sinemet. This may work forseveral years, however, it looses effect after that and produces only harmful side effects. Later on, by a study from Australia (?) indicated that the reason for the lack of effect after some time is that the neorons are dead an gone leaving an empty spacee. But, as far as I know sinemet does not cause the death of neurons; if the recent news confirms that sinemet is causing the death of neurons, I am not aware of that. I caught in the TV news (CNN Headlinr Newws at 10.30 PM (9.30 PM ET on 31May2002) a glimpse of such bad effect of sinemet; I got curious and watched the 11.PM (10 PM ET) version of the same news; however, this happened to be another edition, in which they have omitted thi part of the news. Raj [log in to unmask] ************* ----- Original Message ----- From: "Kathleen Cochran" <[log in to unmask]> To: <[log in to unmask]> Sent: Sunday, June 02, 2002 12:10 PM Subject: Re: Debate about the > In a message dated 6/2/2002 3:58:10 AM, [log in to unmask] writes: > > << "adds to the debate over whether the current use > > of dopamine in the treatment of Parkinson's could make things worse in the > > long run," > > >> > Rhys, > > My neuro said there is some evidence that dopamine, while effective > initially, in the long run may have some destructive effects. I don't know > the specifics but, like you, would like to know more. > > I found it interesting to read fairly recently about the patient who received > an experimental treatment and, a year later, still showed significant > amelioration of symptoms even though his dopamine levels, which had risen > with treatment, had declined to their original levels. This suggests to me > that dopamine depletion is only part of a complex interaction and focusing on > dopamine alone is not going to get us where we need to go. > > Regards, > Kathleen > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn