Hi!
There are some reports to that effect. References:
1. levodopa induced dyskenesias in normal squirrel monkeys. Ann Neurol
2002 Apr 51 (4) 531.
2. Force overflow and levodopa induced dyskenesias in PD. brain 2002
125:871-9
3. Levodopa strengths and weaknesses, Neurology 2002. 58 (4 Suppl
1)S19-32. This article clnfirms theemergence of motor complications as well
as other side effects. But denies toxic effects of levodopa in viv that has
been seen in in vitro studies. Levodopa is the most effective
anti-parkinsonian drug todate.
4. Risk factors for levodopa-induced dyskinesias in PD. J Neurol 1999.
246, 1127-33.
5. Why delaying levodopa is a good treatment strategy toearly Parkison's
disease Eur J neurol 2000, Suppl. 1, 3-8.
However I was strcuk by a couple of other articles:
1. YOU MUST REMEMBER THIS (how to improve memory) by Brenda Adderly
in better Nutritiion 2000.
2. New Advances in Parkinson's disease by David Perlmutter in
Tonsend Letter for Doctors and Patients. July 2001.
I think this article is written by the gentleman who is
treating PD patients with Glutathione injection in Italy. Glutathione is
given by intravenous injection. People tell me that oral in take of
glutathione does not have any effect. If so, why? Glutathione is a very
tiny molecule. I find it hard to believe that it does not reach the brain,
especially if this is such an important molecule for the function of the
brain and is found low in PD patients just as important as dopamine. It is
apparent that there is no blood brain barrier for this molecule. Is there
any data on long term studies with oral administration of Glutathione with
proper control?
3. Anti-aging with Antioxidants. by Estitta Bushkin in Beter
Nutrition Feb 2000.
You can find these and other very useful articles at
www.findarticles.com
Raj
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----- Original Message -----
From: "Rhys Morris" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Sunday, June 02, 2002 4:57 AM
Subject: Debate about the
> This item was recently posted on the UK PDNews service. What caught my
> attention is the comment "adds to the debate over whether the current use
> of dopamine in the treatment of Parkinson's could make things worse in the
> long run,"
>
> I didn't know there was a debate. Does anyone have any more information
> about this?
>
> thanks
>
> ========================================================
>
> Subject: [pdnews] "Brain Protein Identified As Likely Factor In
Parkinson's"
> Date: Fri, 31 May 2002 20:27:48 +0100
>
> This message has been sent to you by the PDNEWS service.
> ----------------------------------------------------------------
>
> >From http://www.guardian.co.uk/uklatest/story/0,1271,-1775045,00.html
>
> [snip]
> >A protein that exists normally in most of the cells in the brain has been
> >identified as a possible factor in the development of Parkinson's
disease.
> >
> >The discovery could point the way to treatments.
> >
> >In lab experiments, when the brain protein alpha-synuclein combines with
> >dopamine in nerve cells it can trigger the production of toxic reactive
> >oxygen molecules that kill the nerves, according to a research team led
> >by Dr Bruce Yankner of Harvard Medical School.
> >
> >If this process operates in patients the same way it does in the
> >laboratory, it could set scientists on the path to potential treatments,
> >Dr Yankner said.
> >
> >But it also adds to the debate over whether the current use of dopamine
> >in the treatment of Parkinson's could make things worse in the long run,
> >he added.
> >
> >The findings appear in the journal Nature Medicine.
> [snip]
>
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>
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