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My Mom has the same problems. Well, not the combative part, but when we tried Seroquel for the hallucinations, they got worse. We were told that about 30% of PWPs who take Sinemet will begin having hallucinations and confusion after about seven years. Mom's problem is that no matter what she takes, other than the carbidopa-levidopa that she takes now, has the opposite effect on her. You might try not giving your Mother the Seroquel for a day or two and see if that helps. You could ask her doctor about Excelon. According to Mom's neuro, it could help ease the hallucinations and there are few or no side effects. Your Mom's neuro might consider switching her to the carbidopa-levidopa instead of Sinemet. I hope this helps. I know how you feel watching her go through this. I used to tell Mother just to tell the people she saw to go away. When she starts talking to someone who's not here, I just remind her that they're not here or whatever. She doesn't see things all the time, though once she did think she had a cat on her lap. Mostly you just have to treat the whole thing lightly and unless she gets really upset about the people she sees, just remind her that there's no one there. Unfortunately, this is one of those Parkinson's things where you just have to do what works for you. Good luck. I hope you find something that helps. Eleanor CG/Mother ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn