He posted the same information a couple of days ago in his askthedoctor
column.
Raj
[log in to unmask]
****************
----- Original Message -----
From: "Emily and Julian Brinac" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Wednesday, June 12, 2002 7:33 PM
Subject: Re: proteins again
> Did anyone asked Dr. Lieberman to confirm the protein information? He is
> a leading authority on PD.
> Emily
> ----- Original Message -----
> From: "Ray Strand" <[log in to unmask]>
> To: <[log in to unmask]>
> Sent: Wednesday, June 12, 2002 1:35 PM
> Subject: proteins again
>
>
> >
> > news from Reuters
> >
> >
> ........................................................................
> ........................................................
> >
> >
> > [Publication Logo]
> >
> > Synuclein-Protein Complexes Render Dopamine Neurotoxic
> >
> >
> >
> > NEW YORK (Reuters Health) May 31 - Alpha-synuclein forms soluble
> > complexes with the anti-apoptotic protein 14-3-3 that appear to cause
> > endogenous dopamine to become toxic to neurons in the substantia
> nigra,
> > according to a study in the June issue of Nature Medicine.
> >
> > This finding may explain the selective loss of dopaminergic neurons in
> > Parkinson's disease, the study authors suggest, and it may ultimately
> > lead to new therapies for the disease, as well as for diffuse
> Lewy-body
> > disease and some variants of Alzheimer's disease.
> >
> > Dr. Bruce A. Yankner, of the Children's Hospital in Boston, told
> Reuters
> > Health that "until now, the combination of alpha-synuclein with 14-3-3
> > protein was not known to cause neuron degeneration."
> >
> > Dr. Yankner and associates found that transfection of alpha-synuclein
> in
> > primary cultures of nondopaminergic human cortical neurons (HCN cells)
> > and in human fetal dopaminergic neurons (DAN cells) led to similar
> > expression of the protein. Overexpression of alpha-synuclein increased
> > survival of the HCN cells, but led to increased apoptosis in the DAN
> cells.
> >
> > They then inhibited endogenous dopamine expression in DAN cells and
> > found that apoptosis induced by alpha-synuclein and potentiated by
> > oxidative stress was completely blocked.
> >
> > Autopsy studies showed that alpha-synuclein in the substantia nigra
> was
> > complexed with 14-3-3 protein. This inactivates the anti-apoptotic
> > effect of 14-3-3 protein, and dopamine metabolism subsequently
> promotes
> > apoptosis by acting as a source of reactive oxygen species, the
> authors
> > suggest. They believe that the complexes may also increase neuronal
> > vulnerability to other pro-oxidative agents, such as amyloid
> beta-protein.
> >
> > "It is too early to make any clear predictions regarding treatment,"
> > said Dr. Yankner. "However, if the findings of this paper prove to be
> > important for Parkinson's disease, then preventing alpha-synuclein
> from
> > getting together with the 14-3-3 protein could be a new therapeutic
> > approach to the disease."
> >
> > Nat Med 2002;8:600-606.
> >
> >
> >
> >
> >
> >
> ........................................................................
> ..........................................................
> >
> > Ray Strand
> > Prairie Sky Design
> > -----------------( on the Edge of the Prairie
> byss )---------------
> > when the sky is clear
> > the ground is visible
> > 50/47dx PD/40? onset
> > http://folding.stanford.edu
> > join MSA TEAM CURE
> > #2508
> > }
> >
> >
>
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