Hello Jorge, Kathrynne, Janet, Mary, Murray, Jan, Nilo, Carol, Bob,
Raj, Ivan, Katie, Deborah, Emily/Julian, hello list,
I have been a silent subscriber of your list for a half of a year. I
am not a PWP, I have been a researcher of the Biophysics lab of Tartu
University, Estonia, now retired. We have had here, in Estonia, regular
spring schools on theoretical biology already for 28 years now. I have been
active in all of them, including the 1999 school on memory theory, abstract
of which (Vello & Mati Reeben, pp.42-49, in Estonian) consists a scetch of a
new BIOPHYSICAL theory of the genesis of parkinsonism, essential tremor and
absence epilepsy ( Mati - my son, molecular neurobiologist in Kuopio
University, co-ordinator of an Eurogrant, EC FP5 QLG3-CT-2000-01405
"Cystatin B in epilepsy", http://www.uku.fi/cystatin/)
We are convinced that today it is the time to take BIOPHYSICAL
theories more seriously as
1) the majority of neurodegenerative diseases, including PD, do
demonstrate prion-like mechanisms resulting in accumulation of
biophysically WRONGLY-FOLDED proteins which aggregate in dense-packed
lesions (Lewy bodies,..) not obeying for normal decomposition processes,
2) the 2001 year Nobel prize work in physics (on coherent atomic lasers)
has given us direct experimental evidence that matter and waves/fields are
very tightly interconnected indeed,
3) there are reports about mysterious clusters of young-onset PD
(the case described by M.J.Fox in Canadian television staff, the case
among Pittsburg University physicist's),
4) the chaperonin protein which helps to repair conformations, probably
through biophysical fields, works even in such far models like the
Drosophila model and
5) sensitivity of PD patients to a low frequency (ca 0.75 Hz) movement
stimulation.
We are convinced that important biomolecules are unique not only
biochemically but also BIOPHYSICALLY, they fit not only into the metabolic
pathways but also into the system of organismic and environmental rhythms.
According to our theory based on natural rhythms the main specific
CAUSING mechanism of the mentioned neurodegenerative diseases (PD, essenial
tremor, absence epilepsy) lies in the existence of such powerful but
informationally deviated natural RHYTHMS which happen to fall close to the
normal informationally optimal physiologic rhythms (EEG waves).
Particularly, in the case of PD the alien rhythm threatens the EEG
theta wave, less the delta (alpha/4) and alpha waves. That is why PD is
characterized by a sharp-resonance resting tremor at EEG theta-wave
frequency.
In theory the quantum jump from normal EEG theta wave to alien rhythm
is extremely small in frequency scale (transition from 5.778 Hz to 5.761 Hz)
but significant in quantum numbers (7*23*37 -> 2*2*3*3*3*5*11) which
determine the (Sheldrake's morphic) resonance phenomena of bioatoms and
small biomolecules.
For the EEG delta and alpha waves the quantum jump occurs through the
prime divisors 23*37 -> 2*2*2*2*5*11.
As there are data that PD causes also involuntary changes in breathing
rhythm (PWP-s being afraid to crawl when swimming) and the PD main domain
rhythm 6.25 s is not so far from the human main breathing rhythm 4.27 s the
corresponding quantum jump 7*23 -> 2*5*11 may also obtain an importance .
There exist a variety of evidence that the morphic resonance is caused
by natural (atomic) rhythms and becomes evident for us through CHARGE (in
DNA structures and amino acid residues of proteins) and MASS (in monomers of
non-protein polymers, in mediators, in metabolites, including risk molecules
of PD) NUMBERS.
The first quantum numbers (7*23*37, especially 23 in them) can be
considered as DEFENCE FACTORS, the second quantum numbers
(2*2*3*3*3*5*11, especially 11 in them) as RISK FACTORS favouring a
quantum transition to the PD-rhythm.
Under the attack are enzymes (alpha-synucleine,..) with Mn atoms
(M=55=5*11) and dopaminergic, noradrenergic and serotonergic systems as
dopamine has a mass M = 153; 154=2*7*11 noradrenaline has M = 169 = 13*13
and serotonin has M = 176 = 2*2*2*2*11.
It appears that all the epidemiologically discovered risk factor
molecules have MASS NUMBERS near to a 11-containing or 13-containing
combination of the risk quantum numbers 2*2*3*3*3*5*11, 2*2*2*2*5*11,
2*5*11 and 2*2*2*3*3*13:
- MPTP: M = 173; 176 = 2*2*2*2*11 - evoking agent,
- phenothiazine: M = 198 = 2*3*3*11 - evoking agent,
- 6-hydroxydopamine: M = 169 = 13*13 -(noradrenergic) evoking agent,
- alpha-methylparatyrosine: M = 195 = 3*5*13 - (noradrenergic)
evoking agent,
- cysteinylglycine: M = 176 = 2*2*2*2*11 - accumulating molecule,
recommended as a PD biomarker,
- methanol CH(3)OH: M = 32; 33 = 3*11 - risk factor,
- CCl(4): M = 153.8; 154 = 2*7*11 - risk factor,
- H(2)SO(4): M = 98; 99 = 3*3*11 - risk factor,
- (55)Mn: M = 55 = 5*11, causing factor, accumulating in substantia
nigra up to 18 times,
- (56)Fe-92%+(54)Fe-6%: thus 6% of Fe(2) has M = 110 = 2*5*11 -
element with significant accumulation,
- (197)Au: M = 197.2; 198 = 2*3*3*11, strong accumulation (in
s.nigra),
- (198)Hg-10%: M = 198; 198 = 2*3*3*11, accumulation,
- vitamin D rich nutrition: D(2): M = 396.6; 396 = 2*2*3*3*11,
D(3): M = 384.6; 385 = 5*7*11.
Some of the drug-induced PD forms find also an explanation in this
rhythm/resonance theory:
- reserpine: M = 608; 605 = 5*11*11,
- trifluoperazine: M = 479/483; 484 = 2*2*11*11,
This theory also makes it more easy to understand why the PWP-s
start dislike potatoes (starch M = 162*n, 161=7*23), crave sugar
(monosaccharide hydrate M = 198 = 2*3*3*11, disaccharides M = 342;
341=11*31) and avoid alchohol, beer (ethanol M = 46 = 2*23).
The present theory allows us to make predictions which can be
tested:
1) as the epidemiologic studies from Germany, Japan, USSR and USA have
ascertained that pesticides of fruit gardening is a risk factor for PD but
have not yet cleared up which one of them is to be blamed, so our
rhythm/resonance-based theory can point here to a probable candidate:
malathion (carbophos): M = 330 = 2*3*5*11 as being rather near to
2*2*3*3*3*5*11,
2) the most probable (1:4:9:16:36:49:64:144:196)-frequencies where PD
patients may reveal sensitivity to some kind stimulations are:
6.25 s, 1.56 s, 1.44 Hz, 2.56 Hz, 5.76 Hz, 7.84 Hz, 10.2 Hz, 23.0 Hz, 31.4
Hz
3) the most probable frequencies of the noradrenergic form of PD are
7.44 s, 1.21 Hz, 4.84 Hz, 6.59 Hz, 10.9 Hz, 30.3 Hz.
The present theory has, of course, deeper roots, indicating that
elements of a new biophysical paradigm are already knocking at the door of
the 2000 millennium science. But, as usually in science, a new theory will
not appear in ease, pioneers need a growth time and opponents an
understandig that the existing theories (biochemical medicine) will really
benefit from the ideas of younger brothers (biophysical paradigm).
So happend also in our case, our first 10 pages more general paper to a
Paris conference was not accepted in June 2000 (one referee accepting, two
rejecting).
We write now this mail with an aim to be helpful in many ways:
- for PWP and medical science to strengthen the hope that the
existing symptomatic approach will soon grow to a more causal
theory,
- for curious outway-seeking PWP a new helping tool for independent
search of various possible remedies,
- for us a communication possibility helping to reach to a clear
presentation of our new ideas,
- for medical epidemiology, pharmacy and pesticide industry to get a
simple preliminary test to find out which chemicals might be
PD-causing.
Here are the data about the theoretical parameters N, period T or
frequency 1/T, N/N(opt) and square root (N) of the physiological rhythms and
PD-causing rhythms found as unique parts T = T(0)/N of the galactic year
where T(0) = 205133000 years:
- breathing rhythm:
N = 2*2*2*2*3*3*3*3*5*5*7*7*11*13*17*19*23*29*31,
period T = 4.27 s, N/N(opt) = 1.00, (this parameter shows a
deviation from the informational optimum, at 1.00 we have optimal
Ramanujan's highly composite numbers), square root(N) = n.xxxxx;
(this last parameter is an indicator of powerfulness of a rhythm).
- EEG theta rhythm:
N = 2*2*2*2*2*3*3*3*5*5*7*7*11*13*17*19*23*29*31*37,
5.78 Hz/1.028/n.9971,
- EEG alpha rhythm:
N = 2*2*2*2*2*3*3*3*3*5*5*7*11*13*17*19*23*29*31*37,
9.90 Hz/1.057/n.9797,
- PD domain rhythm (for which there exists a unique composite
extremely near-quadratic N = (n*n-1)-type number:
N = 2*2*2*2*2*3*3*3*3*5*5*5*7*11*11*13*17*19*23*29*31*37,
6.25 s/2.648/n.999999985,
- PD subrhythms: N(s2)=N*2*2, 1.56 s/2.39/n.999999970,
N(s4)=N*4*4, 2.56 Hz/2.73/n.999999940,
N(s6)=N*6*6, 5.76 Hz/3.69/n.999999911,
N(s12)=N*12*12, 23.0 Hz/4.92//n.99999982.
Theoretically most suspicious are molecules with M = n*11 and
M = n*11*11 having a molecular weight close to risk factor quantum numbers
2*2*3*3*3*5*11, 2*2*2*2*5*11 and 2*5*11, that is M = 55, 110, 121, 165, 176,
198, 220, 242, 330, 363, 484, 605.
The less pronounced PD form which attacks noradrenergic
(noradrenaline - M = 169 = 13*13) processes and is usually localized in
other regions of the brain (hypothalamus) has also highly specific
theoretical explanation here:
- domain rhythm
N = 2*2*2*2*2*2*2*2*2*2*3*3*5*5*7*11*13*13*17*19*-*29*31,
7.44 s/4.45/n.999999983,
- the N*3*3 rhythm 1.21 Hz/3.88/n.999999949
- close to EEG theta wave rhythm N = N*6*6, 4.84 Hz/5.17/n.999999898
- close to EEG alpha wave rhythm N = N*9*9,
10.9 Hz/5.81/n.999999847,introducing a quantum jump
23*37 -> 2*2*2*3*3*13.
It seems that the 11-containing quantum numbers are important in the
genesis of sporadic PD and the 13-containing quantum number molecules may
also play an ignition of the PD processes when introduced in big doses as in
animal models.
BTW, in this theory the subrhythms appear in the same quadratic manner
as the spectral series of the hydrogen atom in Balmer/Rydberg/Bohr quantum
theory.
Do not hesitate asking questions, they will help you and us.
A remark: C(13), O(18) and S(34) slightly raise the molecular weight
giving 0.3% - 4% M+1 or M+2 molecules), it seems that 3-valent N when in
symmetrical position (like in MPTP) can weakly tie two more H.
Vello Reeben
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