Hi! Vello: Thank you for your email on the biophysical hypothesis on the origin of PD, ET and epilepsy. Since I am not a biophysicist, most of the info in this email are above me. However, I have a couple of questions for you. 1. You invoke a prion hypothesis in the beginning. Aren't they infective? Do you mean to say PD is infective? 2. The biophysical changes in the parameers that you have elaborated -Are they the cause or the results of the disease? 3. If so, what can one do to cure the disease, at least hypothetically? 4. I remember reading about electromagnetic treatment for PD some time ago. Whatever happened to those studies and why it is not popular any more? Thanks. Raj [log in to unmask] *************** ----- Original Message ----- From: "Vello Reeben" <[log in to unmask]> To: <[log in to unmask]> Sent: Thursday, June 20, 2002 6:32 AM Subject: on a causal theory of PD > Hello Jorge, Kathrynne, Janet, Mary, Murray, Jan, Nilo, Carol, Bob, > Raj, Ivan, Katie, Deborah, Emily/Julian, hello list, > > I have been a silent subscriber of your list for a half of a year. I > am not a PWP, I have been a researcher of the Biophysics lab of Tartu > University, Estonia, now retired. We have had here, in Estonia, regular > spring schools on theoretical biology already for 28 years now. I have been > active in all of them, including the 1999 school on memory theory, abstract > of which (Vello & Mati Reeben, pp.42-49, in Estonian) consists a scetch of a > new BIOPHYSICAL theory of the genesis of parkinsonism, essential tremor and > absence epilepsy ( Mati - my son, molecular neurobiologist in Kuopio > University, co-ordinator of an Eurogrant, EC FP5 QLG3-CT-2000-01405 > "Cystatin B in epilepsy", http://www.uku.fi/cystatin/) > > We are convinced that today it is the time to take BIOPHYSICAL > theories more seriously as > 1) the majority of neurodegenerative diseases, including PD, do > demonstrate prion-like mechanisms resulting in accumulation of > biophysically WRONGLY-FOLDED proteins which aggregate in dense-packed > lesions (Lewy bodies,..) not obeying for normal decomposition processes, > 2) the 2001 year Nobel prize work in physics (on coherent atomic lasers) > has given us direct experimental evidence that matter and waves/fields are > very tightly interconnected indeed, > 3) there are reports about mysterious clusters of young-onset PD > (the case described by M.J.Fox in Canadian television staff, the case > among Pittsburg University physicist's), > 4) the chaperonin protein which helps to repair conformations, probably > through biophysical fields, works even in such far models like the > Drosophila model and > 5) sensitivity of PD patients to a low frequency (ca 0.75 Hz) movement > stimulation. > > We are convinced that important biomolecules are unique not only > biochemically but also BIOPHYSICALLY, they fit not only into the metabolic > pathways but also into the system of organismic and environmental rhythms. > According to our theory based on natural rhythms the main specific > CAUSING mechanism of the mentioned neurodegenerative diseases (PD, essenial > tremor, absence epilepsy) lies in the existence of such powerful but > informationally deviated natural RHYTHMS which happen to fall close to the > normal informationally optimal physiologic rhythms (EEG waves). > Particularly, in the case of PD the alien rhythm threatens the EEG > theta wave, less the delta (alpha/4) and alpha waves. That is why PD is > characterized by a sharp-resonance resting tremor at EEG theta-wave > frequency. > In theory the quantum jump from normal EEG theta wave to alien rhythm > is extremely small in frequency scale (transition from 5.778 Hz to 5.761 Hz) > but significant in quantum numbers (7*23*37 -> 2*2*3*3*3*5*11) which > determine the (Sheldrake's morphic) resonance phenomena of bioatoms and > small biomolecules. > For the EEG delta and alpha waves the quantum jump occurs through the > prime divisors 23*37 -> 2*2*2*2*5*11. > As there are data that PD causes also involuntary changes in breathing > rhythm (PWP-s being afraid to crawl when swimming) and the PD main domain > rhythm 6.25 s is not so far from the human main breathing rhythm 4.27 s the > corresponding quantum jump 7*23 -> 2*5*11 may also obtain an importance . > > There exist a variety of evidence that the morphic resonance is caused > by natural (atomic) rhythms and becomes evident for us through CHARGE (in > DNA structures and amino acid residues of proteins) and MASS (in monomers of > non-protein polymers, in mediators, in metabolites, including risk molecules > of PD) NUMBERS. > The first quantum numbers (7*23*37, especially 23 in them) can be > considered as DEFENCE FACTORS, the second quantum numbers > (2*2*3*3*3*5*11, especially 11 in them) as RISK FACTORS favouring a > quantum transition to the PD-rhythm. > Under the attack are enzymes (alpha-synucleine,..) with Mn atoms > (M=55=5*11) and dopaminergic, noradrenergic and serotonergic systems as > dopamine has a mass M = 153; 154=2*7*11 noradrenaline has M = 169 = 13*13 > and serotonin has M = 176 = 2*2*2*2*11. > It appears that all the epidemiologically discovered risk factor > molecules have MASS NUMBERS near to a 11-containing or 13-containing > combination of the risk quantum numbers 2*2*3*3*3*5*11, 2*2*2*2*5*11, > 2*5*11 and 2*2*2*3*3*13: > > - MPTP: M = 173; 176 = 2*2*2*2*11 - evoking agent, > - phenothiazine: M = 198 = 2*3*3*11 - evoking agent, > - 6-hydroxydopamine: M = 169 = 13*13 -(noradrenergic) evoking agent, > - alpha-methylparatyrosine: M = 195 = 3*5*13 - (noradrenergic) > evoking agent, > - cysteinylglycine: M = 176 = 2*2*2*2*11 - accumulating molecule, > recommended as a PD biomarker, > - methanol CH(3)OH: M = 32; 33 = 3*11 - risk factor, > - CCl(4): M = 153.8; 154 = 2*7*11 - risk factor, > - H(2)SO(4): M = 98; 99 = 3*3*11 - risk factor, > - (55)Mn: M = 55 = 5*11, causing factor, accumulating in substantia > nigra up to 18 times, > - (56)Fe-92%+(54)Fe-6%: thus 6% of Fe(2) has M = 110 = 2*5*11 - > element with significant accumulation, > - (197)Au: M = 197.2; 198 = 2*3*3*11, strong accumulation (in > s.nigra), > - (198)Hg-10%: M = 198; 198 = 2*3*3*11, accumulation, > - vitamin D rich nutrition: D(2): M = 396.6; 396 = 2*2*3*3*11, > D(3): M = 384.6; 385 = 5*7*11. > Some of the drug-induced PD forms find also an explanation in this > rhythm/resonance theory: > - reserpine: M = 608; 605 = 5*11*11, > - trifluoperazine: M = 479/483; 484 = 2*2*11*11, > > This theory also makes it more easy to understand why the PWP-s > start dislike potatoes (starch M = 162*n, 161=7*23), crave sugar > (monosaccharide hydrate M = 198 = 2*3*3*11, disaccharides M = 342; > 341=11*31) and avoid alchohol, beer (ethanol M = 46 = 2*23). > > The present theory allows us to make predictions which can be > tested: > 1) as the epidemiologic studies from Germany, Japan, USSR and USA have > ascertained that pesticides of fruit gardening is a risk factor for PD but > have not yet cleared up which one of them is to be blamed, so our > rhythm/resonance-based theory can point here to a probable candidate: > malathion (carbophos): M = 330 = 2*3*5*11 as being rather near to > 2*2*3*3*3*5*11, > 2) the most probable (1:4:9:16:36:49:64:144:196)-frequencies where PD > patients may reveal sensitivity to some kind stimulations are: > 6.25 s, 1.56 s, 1.44 Hz, 2.56 Hz, 5.76 Hz, 7.84 Hz, 10.2 Hz, 23.0 Hz, 31.4 > Hz > 3) the most probable frequencies of the noradrenergic form of PD are > 7.44 s, 1.21 Hz, 4.84 Hz, 6.59 Hz, 10.9 Hz, 30.3 Hz. > The present theory has, of course, deeper roots, indicating that > elements of a new biophysical paradigm are already knocking at the door of > the 2000 millennium science. But, as usually in science, a new theory will > not appear in ease, pioneers need a growth time and opponents an > understandig that the existing theories (biochemical medicine) will really > benefit from the ideas of younger brothers (biophysical paradigm). > So happend also in our case, our first 10 pages more general paper to a > Paris conference was not accepted in June 2000 (one referee accepting, two > rejecting). > > We write now this mail with an aim to be helpful in many ways: > > - for PWP and medical science to strengthen the hope that the > existing symptomatic approach will soon grow to a more causal > theory, > - for curious outway-seeking PWP a new helping tool for independent > search of various possible remedies, > - for us a communication possibility helping to reach to a clear > presentation of our new ideas, > - for medical epidemiology, pharmacy and pesticide industry to get a > simple preliminary test to find out which chemicals might be > PD-causing. > > Here are the data about the theoretical parameters N, period T or > frequency 1/T, N/N(opt) and square root (N) of the physiological rhythms and > PD-causing rhythms found as unique parts T = T(0)/N of the galactic year > where T(0) = 205133000 years: > - breathing rhythm: > N = 2*2*2*2*3*3*3*3*5*5*7*7*11*13*17*19*23*29*31, > period T = 4.27 s, N/N(opt) = 1.00, (this parameter shows a > deviation from the informational optimum, at 1.00 we have optimal > Ramanujan's highly composite numbers), square root(N) = n.xxxxx; > (this last parameter is an indicator of powerfulness of a rhythm). > - EEG theta rhythm: > N = 2*2*2*2*2*3*3*3*5*5*7*7*11*13*17*19*23*29*31*37, > 5.78 Hz/1.028/n.9971, > - EEG alpha rhythm: > N = 2*2*2*2*2*3*3*3*3*5*5*7*11*13*17*19*23*29*31*37, > 9.90 Hz/1.057/n.9797, > - PD domain rhythm (for which there exists a unique composite > extremely near-quadratic N = (n*n-1)-type number: > N = 2*2*2*2*2*3*3*3*3*5*5*5*7*11*11*13*17*19*23*29*31*37, > 6.25 s/2.648/n.999999985, > - PD subrhythms: N(s2)=N*2*2, 1.56 s/2.39/n.999999970, > N(s4)=N*4*4, 2.56 Hz/2.73/n.999999940, > N(s6)=N*6*6, 5.76 Hz/3.69/n.999999911, > N(s12)=N*12*12, 23.0 Hz/4.92//n.99999982. > > Theoretically most suspicious are molecules with M = n*11 and > M = n*11*11 having a molecular weight close to risk factor quantum numbers > 2*2*3*3*3*5*11, 2*2*2*2*5*11 and 2*5*11, that is M = 55, 110, 121, 165, 176, > 198, 220, 242, 330, 363, 484, 605. > > The less pronounced PD form which attacks noradrenergic > (noradrenaline - M = 169 = 13*13) processes and is usually localized in > other regions of the brain (hypothalamus) has also highly specific > theoretical explanation here: > - domain rhythm > N = 2*2*2*2*2*2*2*2*2*2*3*3*5*5*7*11*13*13*17*19*-*29*31, > 7.44 s/4.45/n.999999983, > - the N*3*3 rhythm 1.21 Hz/3.88/n.999999949 > - close to EEG theta wave rhythm N = N*6*6, 4.84 Hz/5.17/n.999999898 > - close to EEG alpha wave rhythm N = N*9*9, > 10.9 Hz/5.81/n.999999847,introducing a quantum jump > 23*37 -> 2*2*2*3*3*13. > > It seems that the 11-containing quantum numbers are important in the > genesis of sporadic PD and the 13-containing quantum number molecules may > also play an ignition of the PD processes when introduced in big doses as in > animal models. > > BTW, in this theory the subrhythms appear in the same quadratic manner > as the spectral series of the hydrogen atom in Balmer/Rydberg/Bohr quantum > theory. > > Do not hesitate asking questions, they will help you and us. > > A remark: C(13), O(18) and S(34) slightly raise the molecular weight > giving 0.3% - 4% M+1 or M+2 molecules), it seems that 3-valent N when in > symmetrical position (like in MPTP) can weakly tie two more H. > > Vello Reeben > > _________________________________________________________________ > MSN Photos is the easiest way to share and print your photos: > http://photos.msn.com/support/worldwide.aspx > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn