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charlotte, thanks a lot paula ----- Original Message ----- From: "charlotte A mancuso" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, June 26, 2002 1:34 PM Subject: Comtan Re: Symptoms > Hi Paula, > > Comtan acts the way Tasmar does, but it does not have the precautions > regarding the liver. It's excreted through the kidneys. It does nothing > on its own; it enhances Sinemet by inhibiting COMT, which metabolized > Sinemet, I believe in the peripheral blood stream, and therefore lessens > the Sinemet to the brain. From PubMed, Medline: "...The COMT inhibitors > entacapone (Comtan) and tolcapone (Tasmar) dose-dependently inhibit the > formation of the major metabolite of levodopa, 3-O-methyldopa, and > improve the bioavailability and reduce the clearance of levodopa without > significantly affecting its absorption. They are useful adjuncts to > levodopa in patients with end-of-dose fluctuations. ..." > > I hope this helps. > > Charlotte > > > On Wed, 26 Jun 2002 08:57:43 -0500 patandpaula <[log in to unmask]> > writes: > > charlotte, what is comtan?? thanks paula > > ----- Original Message ----- > > From: "charlotte A mancuso" <[log in to unmask]> > > To: <[log in to unmask]> > > Sent: Wednesday, June 26, 2002 2:27 AM > > Subject: Re: Symptoms > > > > > > > George/Scott, > > > > > > It's none of my business, and I'm jumping into the middle of a > > thread, > > > but I can't help commenting on the dosages I'm reading for Requip > > > especially (for what it's worth). > > > > > > According to my Movement Disorder Specialist, and everything I've > > heard > > > and read about Requip, 6mg of Requip is just about the very least > > you can > > > take for a therapeutic effect. Now I suppose that some people may > > have > > > had a beneficial effect with 4 or 5, but 6-7mg/day is considered > > the > > > start of a therapeutic dose for Requip. You can go up to 24 > > mg/day, > > > although that is the max. > > > > > > Incidentally, the dosing is very different from Mirapex, which, mg > > for > > > mg, is much more potent. I started with Mirapex, and found it > > harder to > > > take than Requip, and found that after trying for months, I > > couldn't get > > > past 1 1/2 mg/day--1/2, 3 times per day. My doctor had me switch > > to 7mg > > > of Requip after a short titration, and I found that, yes indeed, 7 > > mg was > > > just about the equivalent of 1 1/2 mg of Mirapex. The max for > > Mirapex > > > is, I believe, around 6 mg. > > > > > > Also, most people take 25/100, rather than 50/200, although you > > are > > > taking extended release. Extended release doesn't work real well > > for a > > > lot of people. Have you tried regular Sinemet with Comtan? > > > > > > I hope you don't mind my little opinions and ideas. Good luck to > > you > > > both. > > > > > > Charlotte Mancuso > > > > > > On Tue, 25 Jun 2002 23:13:50 -0700 scott burnett > > <[log in to unmask]> > > > writes: > > > > george, > > > > Your situation sounds similar to mine. Same time > > schedule, > > > > similar > > > > problems but add on neck and back pain, fatigue and a feeling of > > > > "not being > > > > right" when I'm off. I recently upped my dosage of requip to 6 > > mg a > > > > day > > > > and that helped some. Stress really makes a difference to me > > so > > > > the issue > > > > of continued work is of real concern. I am changing to what I > > hope > > > > is a > > > > much less stressful position next school year so I evaluate that > > as > > > > time > > > > goes on. I spent several weeks looking into the California > > State > > > > Teachers > > > > Retirement systems disability set up aand it looks pretty good. > > > > Even > > > > though I intend to keep working and adapting my schedule and > > > > workload as > > > > much as I'm allowed, it made me feel alot better to have the > > info at > > > > hand. > > > > Someone from the list put it very well I thought when they > > wrote, > > > > "I have > > > > a cup of energy to use each day, and I have to decide where I > > want > > > > to use > > > > it; at work, with friends or with family." That's not an exact > > > > quote but > > > > you get the point. Somewhere down the road, all of us PWP's > > will > > > > have to > > > > make a personal choice. When and where it will be is up to us. > > > > Scott from California > > > > > > > > > > ---------------------------------------------------------------------- > > > > To sign-off Parkinsn send a message to: > > > > mailto:[log in to unmask] > > > > In the body of the message put: signoff parkinsn > > > > > > > > ---------------------------------------------------------------------- > > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > > In the body of the message put: signoff parkinsn > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn