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Hello George,
You asked to hear from someone with a similar situation and for thoughts
to discuss with your Neuro.  I can sympathize with your dilemma.  I am
not an MD but I have been my wife's caregiver for over 20 years.  Having
said that, here is a summary of our experience.  First thing that
matters is the known fact that as time progresses the medication has
less and less effect.  We ended up with a 3/4 hour schedule starting at
6 am [5 doses daily]. You don't mention how long you have been on these
meds but I would assume that you have used them for many years.  No two
people react the same but you might ask about using Permax to give
Sinemet an extra boost.  We found CR to be very erratic as to response
and longevity.  We also found generic Levadopa to be of little value.
My wife did not respond to it and we went back to regular Sinemet.  We
found that Comtan will extend the "on" time also.  She was on Permax,
Sinemet and Comtan 5x daily for quite a few years and it worked great up
until this past year.  At that time the medications slowly became
erratic and unpredictable.  That was when we decided to have a DBS
operation.  She now has no tremor and her speech and walking problems
have greatly improved.  I hope that we have helped you in some way.
Ron

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