Hello Paul,
you write
P.L.:>At first I thought the 'causal theory' thread was someone having
>fun...but over time it is becoming clear (hah!) that its proponent is
>serious about the theory...or extraordinarily serious about pulling >our
legs. In the former case, I would suggest trying to make the point >without
esoteric formulas and theorem names.
........
> With all this in my background, I HAVE NOT THE VAGUEST CONCEPT ABOUT
>WHICH THIS MAN SPEAKS.
V.R.: Well, as I have written already, in my first mail I tried to present
the SPECIFIC CORE of a new hypothesis on the genesis of PD based on a
rhythms-based approach. I am sorry that the specific language needed for
that made difficult to catch the main idea.
Actually the MAIN IDEA is not complicated at all: all the normal
physiological processes are rhythmical, in digestive system, in circulatory
system, in nervous system. Our heart beats rhythmically, we breathe
rhythmically.
By means of various scientific instruments we can record the oscillating
TIME SEQUENCIES in all these parameters, computers and mathematical
algorithms allow us to find out whether there exist certain PERIODICALLY
REPEATING EVENTS in them. The latter mentioned events are called RHYTHMS or
CYCLES or PERIODS (or REAL DURATIONS by Henri Bergson) or with a predicative
also as WAVES (the EEG alpha-wave).
The information about rhythms is presented as full SPECTRAL CURVES in
co-ordinates intensity-time or intensity-frequency, or, as usually in
medicine, as simplified BAR CURVES or numerical BAR DATA showing us how
many EEG waves fall into a typical alpha zone, beta zone etc.
If an event repeats in a way as the metronome beats the spectral curve
will show us only a narrow peak. It shows then that there is a sharp
resonance in the system.
In normal physiology all the rhythms are interlinked with each
other and modulate each other so that any sharp resonance is not seen.
If one's heart is beating like a metronome it is an indicator of a serious
disease.
The same we can see in the case of tremor. Normal spectral curves of the
tremor have a wide spectrum. Only in the case of a strong fatigue, like it
is noticed in overtired pilots and drivers case, one can see a sharp tremor
spectrum and that for a short time.
The fact that in the case of the PD the spectral curves of the resting
tremor demonstrate a sharp peak at 5 Hz together with sharp harmonics at 10
and 20 Hz clearly says: there is something very special. Just in temporal
processes. Being a resonance of a mysterious origin.
So we have real reasons to think that just a rhythm-based approach is
adequate for a study of this special phenomenon.
Thus, general aspects of the core of the present causal theory can easily
be described.
However, the next step needs already some digging into our NEW
GENERAL theory of natural rhythms.
Here we have to tell you that our turn to a theory of the genesis of
the Parkinson's disease did not appear on an empty place, has not been
accidental:
- our biophysical lab has a 40 years experience in the study of various
physiological rhythms, especially circulatory rhythms,
- in our desire to understand the biophysical mechanisms of human
physiological rhythms we discovered that they well fit into the great
system of environmental, climatic, astronomic rhythms which all happened
to be tied with the GALACTIC YEAR,
- we discovered that a great part of all the rhythms discovered in
variuos sciences up to now can be described as SPECIAL INTEGER parts of
the galactic year T(0),
- we discovered that an integer part of the galactic year T(0)/N obtains a
status of an essential natural rhythm in the case
1) when it enables MAXIMAL TIES with all the other such integer parts,
when it can go into the "green versatile highway" of the evolution,
mathematically when N is a highly composite number by Ramanujan (h.c.n); a
nice example for understanding this criterion of informational optimum is a
timetable of city buses: when the full period of circulation is a Ramanujan
number (in minutes) we have maximum number of versions to regulate the
frequency of traffic by means of the number of buses on line keeping all the
time a convenient full-minute timetable; BTW, we have got from our ancestors
just such system of time: 12, 24, 60, 360, in Plato's ideal town was just
5040 inhabitants;
2) when this ramanujanian N is at the same time a near-quadratic number (N
= a^2 +- epsilon); this criterion is the same as in Balmer-Rydberg-Bohr
theory of the spectral lines of the hydrogen atom; there are only two N=a^2
type Ramanujan numbers (4, 36) and only eight
N=a^2-1 type numbers; all of them give us important natural rhythms; the
domain number of PD-rhythms we are pointing to is also a N=a^2-1 number but
with a deviation from the Ramanujan optimum 2.65 times,
- in our attempts to understand the nature of the 11 sec rhythm of blood
pressure and of vasomotor system, putting question why it is so different
from the heart rate rhythm and its variations, we paid attention to such
GROUPS of natural rhythms which are described by h.c.n.-s with general
highest prime divisor p(max); it appears that the main physiological rhythms
of mammals are described by the following six groups of h.c.n.-s where the
N(19), N(23) and N(31) groups give us CLOSE-SYSTEM (mathematically
imaginary) rhythms connected with compact structures (heart, lung,..) and
N(29), N(37) and N(41) groups give us OPEN-SYSTEM (mathematically real)
rhythms connected with distributed structures (arterioles, erythrocytes,
neurons); these ideal ramanujanian rhythm groups are in the following range
of time:
N(19) - Im: 107 d - 6.13 h temperature, metabolism
N(23) - Im: 1.17 d - 4.00 min digestive tract
N(29) - Re: 11.6 min - 8.27 s vasomotor system
N(31) - Im: 22.4 s - 11.2 Hz heart, breathing
N(37) - Re: 11.6 Hz - 1390 Hz brain, phonetics, music
N(41) - Re: 474 Hz - 56.8 kHz phonetics, music
Physiological tremor is connected with N(37) brain waves but the
PD-rhythms belong to the N(31) group of CLOSED-SYSTEM rhythms! Just that
circumstance is important in understanding such facts that the PD-rhythms
form in a LOCAL area of the brain CLOSED zones with a continuous irritation,
that they create a phenomenon of movement freezing, a need for a threshold
overcoming, in various muscles a phenomenon of (closed) rigidity.
The phenomenon of bradykinesia, of movement slowness is understood in our
model so: at the beginning the quantum jump to alien rhythm happens at EEG
theta wave, then the resting tremor is the main symptom of PD, at this
frequency the deviation of the PD-rhythm from the optimum is 3.69 times.
Now look, the most less deviation, 2.39 times, has a NINE TIMES slower
PD-rhythm which has a period 1.56 sec instead of 5.76 Hz. Thus, in the
course of time it is energetically useful to overcome to this slow rhythm.
The phenomenon of handwriting change, at first still clear but very small,
is understood so: normally the handwriting is learned under the quadratic
rhythms (as in handwriting the main figure is an ellipse together with its
translation shifts) which are connected with the quantum prime dividers 2^n.
After the quantum jump there appear smaller sub-rhythms of the 2^n type
which seem to cause such a very peculiar phenomenon.
Vello Reeben
>From: Paul Lauer <[log in to unmask]>
>Reply-To: Parkinson's Information Exchange Network
><[log in to unmask]>
>To: [log in to unmask]
>Subject: Re: on a causal theory of PD
>Date: Sun, 23 Jun 2002 22:45:22 EDT
>
>I believe at the time I defended Jan Abas' theories with the admonition to
>the naysayers that whatever works for him is great whether real or
>imagined.
>But to call it or its tenets 'science' and clothe it in an unintelligible
>litany of scientific sounding claptrap disguised with and wrapped around
>terms which are equated with magic (I had to search google for some of
>them).
>
>At first I thought the 'causal theory' thread was someone having >fun...but
>over time it is becoming clear (hah!) that its proponent is >serious about
>the theory...or extraordinarily serious about pulling >our legs. In the
>former case, I would suggest trying to make the point >without esoteric
>formulas and theorem names. This is a PD list and not >a seminar in
>Gaussian mathematics (I used that term because it sprang >to mind. I'm sure
>it's not applicable to the proponent's argument but >for me it is equally
>obscure). I am reasonably literate. I have a BSCE >in Civil Engineering, a
>license to practice >Professional Engineering >in NY and CT, an MBA and I
>am AbD (academic joke lingo for a PhD "all >but dissertation" meaning
>really that the PhD was never completed). I >read the New York Times and
>Wall Street Journal daily. OK, so
>not cover to cover but enough to consider myself reasonably well >informed
>as a result. I am a graduate of the US Army Command and >General Staff
>College,The National Defense University Security >Management Course, The
>Army War College (like getting a PhD in War >Management) and a member of
>the Beta Gamma Sigma Honor Society. A >Million years ago I was a childhood
>member of Mensa, I used to play >chess with three people simultaneously at
>Cafe Rienzi in Greenwich >Village until three in the morning and then go
>play rubber bridge
>for three cents a point which in the 1960s was an expensive game. With >all
>this in my background, I HAVE NOT THE VAGUEST CONCEPT ABOUT WHICH >THIS MAN
>SPEAKS.
>
>Paul h. Lauer
>
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