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Thank you,
 Larry

----- Original Message -----
From: "charlotte A mancuso" <[log in to unmask]>
To: <[log in to unmask]>
Sent: Saturday, June 29, 2002 4:12 AM
Subject: Re: Need more insight on brother in Dallas Texas


> On Fri, 28 Jun 2002 22:33:48 -0400 Diane Stevens <[log in to unmask]>
> writes:
> ...The fact that your brother's tremor responds to Sinemet
> > tells me that he has a brain syndrome that includes damage to the
> > substantia nigra.
>
> With all due respect, yes, this "brain syndrome" is called Parkinson's
> Disease.  I don't mean to sound sarcastic, but a positive response to
> Sinemet is how many neurologist's conclude that a person has PD.  Also,
> PD is a result of dopamine-producing brain cells dying in the Substantia
> Nigra--that's what PD is.  IMHO, it's not clear to me, from what I've
> read about Larry's brother's symptoms, that he has shown Parkinson's
> Plus, except perhaps that he has progressed so fast and so severely.
>
> I do agree, though, that he should be evaluated by another neurologist
> that specializes in, and is up to date on PD and it's therapies.
>
> Just my two cents worth.
>
> Charlotte Mancuso
>
>
> On Fri, 28 Jun 2002 22:33:48 -0400 Diane Stevens <[log in to unmask]>
> writes:
> > Dear Larry ,  The fact that your brother's tremor responds to Sinemet
> > tells me that he has a brain syndrome that includes damage to the
> > substantia nigra. but the other more devastatimg symptoms lead me to
> > believe he has what neurologists call a parkinson's plus syndrome or
> > perhaps another illness has ocurred on top of the PD  So  I would
> > take
> > him to a movement disorder specialist as soon as possible.  Contact
> > the
> > local office of the APDA, NPF or UPF for a referral.  Diane
> >
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