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On Fri, 28 Jun 2002 22:33:48 -0400 Diane Stevens <[log in to unmask]> writes: ...The fact that your brother's tremor responds to Sinemet > tells me that he has a brain syndrome that includes damage to the > substantia nigra. With all due respect, yes, this "brain syndrome" is called Parkinson's Disease. I don't mean to sound sarcastic, but a positive response to Sinemet is how many neurologist's conclude that a person has PD. Also, PD is a result of dopamine-producing brain cells dying in the Substantia Nigra--that's what PD is. IMHO, it's not clear to me, from what I've read about Larry's brother's symptoms, that he has shown Parkinson's Plus, except perhaps that he has progressed so fast and so severely. I do agree, though, that he should be evaluated by another neurologist that specializes in, and is up to date on PD and it's therapies. Just my two cents worth. Charlotte Mancuso On Fri, 28 Jun 2002 22:33:48 -0400 Diane Stevens <[log in to unmask]> writes: > Dear Larry , The fact that your brother's tremor responds to Sinemet > tells me that he has a brain syndrome that includes damage to the > substantia nigra. but the other more devastatimg symptoms lead me to > believe he has what neurologists call a parkinson's plus syndrome or > perhaps another illness has ocurred on top of the PD So I would > take > him to a movement disorder specialist as soon as possible. Contact > the > local office of the APDA, NPF or UPF for a referral. Diane > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn