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Ervin asked: Charley, what is your experience with ReQuip. Thank You. Ervin McCarthy My main problems with PD are stiff slow movement with some shuffling and freezing. Tremor has been controlled since I started with just Selegiline and Amantadine about 9 years ago. As the slow movement (and sometimes slow thought) became more of a problem, Parlodel and finally Sinemet CR 50-200 were added. About 3-4 years ago, when I started to have extreme problems with slowness, my neurologist replaced Parlodel and Amantadine with Requip, increasing the Sinemet CR from 3 to 4 times/day. It seems to work best for me when I take the Requip at the same time as the Sinemet CR. My neuro later added the Amantadine back, but just twice/day, not the previous three or four. I also now take one Requip (1 mg) with Sinemet CR 50-200 four times/day and a fifth Sinemet CR alone when I go to bed at night. "Sleep attacks" seemed to be associated with Requip however (within 30 minutes of taking it). But they have become much less of a problem this past year. (It is interesting to me that this lessening of sleep attacks seems to coincide with me beginning to take Dr. Perlmutter's dietary supplement "brainsustain" and the Q- 10 and NADH he recommends.) I have been taking SAM-e for several years to help with mood. I think that the SAM-e acts as a precursor for Glutathione. Since I get my medical care from a HMO, I doubt if they would approve the Glutathione by injection that Dr. Perlmutter recommends. I see it as a package deal. My body moves best when I take Requip at the same time as the Sinemet CR. Amantadine seems to increase the effect of the Requip/ Sinemet CR combination for me. Are my problems with PD solved. NO! But my wife and son are witnesses to my daily "Mr. Hyde - Dr. Jekyl" routine. I wake up in an awful stiff state. Sometimes my wife has to help me sit up in bed. I shuffle to the toilet and then to the kitchen to take my first dose of Selegiline/ Requip/Sinemet CR w/ orange juice. Later I take SAM-e. With breakfast I take the Amantadine, Q-10, and "brainsustain." The transformation gradually takes place. About an hour after breakfast, although I frequently still feel weak, I can do a T'ai Chi and cane form for exercise (and then walk or work in my garden if I want to.) After my second dose of Requip/Sinemet CR (about 9:00 a.m.), I usually am "on" (although still a little slow compared to "normal" people) through my second dose of Selegiline/Amantadine w/lunch and third dose of Requip/ Sinemet CR after lunch. About two hours after lunch, I take another SAM-e and the NADH. I need to take a long break later in the afternoon. I take my fourth dose of Requip/Sinemet CR about 5:00 p.m. Which takes me through dinner until about 9:00 p.m. Things begin to get very slow again about then. So I take my last Sinemet CR about 9:30 p.m. and go to bed about an hour later. I usually am able to sleep through the night now and begin the routine over again when I wake up about 5:00 a.m. A recent change from four to five Sinemet CR 50-200 seems to have been very effective in lessening unpredicted "off times." I will add that I can occasionally stay up late. (Like tonight and type this.) But the next day I pay for it with slow movement and freezing. Sorry for the long reply to your short question Ervin. But I think of my meds being together in a package. Charley 51, diagnosed 1993, PD symptoms began 2-3 years before that. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn