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hi all i think i might have to add this one to my book list on my website janet ---------------------------------------------------------------------- Frontal-Subcortical Circuits in Psychiatric and Neurological Disorders edited by David G. Lichter and Jeffrey L. Cummings, 448 pp, $75, Guilford Publications, New York, NY, 2000. This text provides an updated and expanded review of the frontal-subcortical (FSC) circuits and their relationship to an array of psychiatric and neurologic disorders. Alexander, DeLong, and Strick initially proposed 5 circuits that originate in the frontal lobes and project to the striatum, then to the globus pallidus and substantia nigra, then to the thalamus, and finally back to the frontal lobes. The 3 FSC circuits involved in behavior and cognition include the dorsolateral prefrontal (DLPF) circuit, the lateral orbitofrontal (OF) circuit, and the anterior cingulate (AC) circuit. The neuroanatomy, neurochemistry, and neurophysiology of these circuits are reviewed in detail, and 2 additional circuits with neurobehavioral relationships (medial orbitofrontal and inferotemporal / posterior parietal) are proposed. The cognitive and behavioral changes associated with dysfunction in each circuit are reviewed. The interactions between FSC circuits and psychiatric disorders (eg, depression, obsessive compulsive disorder, addiction, schizophrenia, and attention deficit / hyperactivity disorder) and neurologic disorders (eg, Parkinson disease, dementia with Lewy bodies, postencephalitic parkinsonism, progressive supranuclear palsy, disinhibition- dementia- parkinsonism- amyotrophy complex, multiple system atrophy, spinocerebellar ataxia, corticobasal degeneration, basal ganglia calcification, Huntington disease, Wilson disease, neuroacanthocytosis, Sydenham chorea, and Gilles de la Tourette syndrome) are described. The authors also review the functional development of FSC circuits, the neuropharmacology of FSC circuits, and the neurobehavioral effects of surgery on FSC circuits (psychosurgery). This book is outstanding. The editors have chosen the topics and authors well, and chapter 1 (which they wrote) provides a superb overview of the salient points of the text. Most chapters are authored by reputable clinicians and/or investigators with considerable expertise in the topics they review. Most chapters also include up-to-date references, with many citations published in 2000. The figures, tables, and illustrations are well-chosen complements to the text. The material provides ample clinical applicability since most of the psychiatric and neurologic disorders associated with FSC dysfunction are reviewed, and classes of agents with documented and potential therapeutic utility are also described. There are few weaknesses. There is considerable overlap across several chapters covering the DLPF, OF, and AC circuits, which makes reading the entire text cumbersome but does allow most chapters to stand alone if read individually. More attention could have been given to frontotemporal dementia. In summary, this is the finest compilation of the brain-behavior relationships involving FSC circuits that I have read. The text is particularly useful for educating neurology and psychiatry residents and fellows; I would recommend it to trainees above any other text of its kind. This book is a "must-read" for all behavioral neurology and neuropsychiatry fellows and should be included in all neurology and psychiatry libraries. Reviewed by Bradley F. Boeve, MD Rochester, Minn SECTION EDITOR: SUSAN T. IANNACCONE, MD 2002 American Medical Association. http://archneur.ama-assn.org/issues/v59n7/ffull/nbk0702-3.html janet paterson: an akinetic rigid subtype, albeit primarily perky, parky pd: 55/41/37 cd: 55/44/43 tel: 613 256 8340 email: [log in to unmask] smail: 375 Country Street, Almonte, Ontario, Canada, K0A 1A0 a new voice website: http://www.geocities.com/janet313/ ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn