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Raj, Thank you for the information. But I understand that those studies involved giving very large doses of SAM-e. I have taken up to 800 mg SAM-e/day. This may have caused some insomnia. I have no problems with 400 mg./day and feel and move better. No apparent interaction problems with my other PD meds (Selegiline, Amantadine, Requip, Sinemet CR 50-200). I am experimenting with 600 mg/day SAM-e now (2 x 200 mg. in morning and 1 x 200 in early afternoon). Charley ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn