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http://www.geocities.com/doncyberdadmckinley/ ----- Original Message ----- From: "janet paterson" <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, July 09, 2002 10:28 AM Subject: WEMOVE: Budipine As Adjunct Therapy in PD > Budipine provides additional benefit in patients with parkinson disease > receiving a stable optimum dopaminergic drug regimen > > Budipine is an effective adjunct treatment for Parkinson's disease, > according to this report. > > Budipine has a complex pharmacological profile with actions on > dopaminergic, GABAergic, cholinergic, norepinephrinergic, and > serotoninergic systems. > > 99 patients were randomized to receive placebo or budipine, titrated up to > 60 mg/day for 16 weeks. > > Patients were on stable levodopa and bromocriptine treatment, with optional > selegiline. > > Mean score on the Columbia University Rating Scale fell from approximately > 35 to 20 in the treated group, versus 34 to 30 in the placebo group (p<0.001). > > Significant differences between the two groups were obtained for tremor, > rigidity, and akinesia. > > Adverse events were significantly more common in the budipine-treated > group, and included dizziness, dry mouth, loss of appetite, nervousness, > and visual dysfunction. > > H Przuntek, S Bittkau, H Bliesath, U Büttner, G Fuchs, J Glass, H Haller, T > Klockgether, P Kraus, L Lachenmayer, D Müller, T Müller, B Rathay, J > Sgonina, V Steinijans, E Teshmar, G Ulm, D Volc > Arch Neurol 2002;59:803-806 > > Copyright 2002 WE MOVE > http://www.wemove.org > > janet paterson: an akinetic rigid subtype, albeit primarily perky, parky > pd: 55/41/37 cd: 55/44/43 tel: 613 256 8340 email: [log in to unmask] > smail: 375 Country Street, Almonte, Ontario, Canada, K0A 1A0 > a new voice website: http://www.geocities.com/janet313/ > HI SIS HAVE U GOT ANY OF MY EMAILS TO U CYBER DAD---------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn