There is a young onset PD man in our support group who has had PD for about 10 years for sure, probably longer (current age 51). He has been taking Sinemet for years, and it has usually been effective. He has taken various agonists in past years, and they produced undesired side-effects. He had a palidotomy about 5 years ago which produced favorable results for about 3 1/2 years. About a year ago he took a considerable turn for the worse: He was also taking Tasmar [and getting liver function tests from time to time which were uniformly negative for problems] when, over a period of about two weeks he gradually lost his ability to stand alone or walk. The fingers on one hand curled in, and the fingers will not extend out even with considerable force. The changes seemed much too fast for PD, but much too slow for a stroke. He is still mentally sharp. When I helped take him for an MRI [no problems seen in MRI pictures], his arms and hands were yellow. [For those who can remember when oleomargerine was white and came with a yellow-orange dye packet: The color was just like the dye when the margerine was partly pale yellow and partly orangey - the orangey color.] I immediately thought juandice, but his eyes were very clear and the eyeballs were very white. {This symptom disappeared in a very few days.}. There are deer and ticks in his yard. I thought Lyme disease. Lyme disease is seen frequently in our area. I understand he was tested for Lyme and test was negative. The MD's are stumped? Any ideas? Will J. ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn