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I will try to stick my 2 cents in at this point and hopefully not get overly technical about same - references are provided, but as a parky and biochemist I must speak up ..... The actions of Alpha Lipoic and N. Acetyl Carnitine have been known about and known to aid parkies for over 20 years .... While we are on the subject of Glutathione repelenishment, we must not ignore the action of Milk Thistle - Silymarin - which takes care of replenishment of GSH in the liver and also removes a host of toxins from Carbon tet. to acetomenaphin and doxycycline 34 N-acetyl cysteine86 and alpha-lipoic acid contribute to GSH repletion and are also potent antioxidants. They like so many tinngs must be taken in the correct ratio and together to achieve the full benefit in restoring GSH. Lately we have had Reuters pick up on them as energy boosters as if this were something new. Acetyl-L-carnitine is a mitochondrial energy carrier, activating transport into the mitochondria of fatty acids to be used for energy. With the evidence so overwhelming that GSH depletion is a central event in PD,32,33,37 and that the degree of GSH depletion is worse in advanced disease effective repletion of GSH must be a therapeutic priority. Combined intravenous and oral GSH replacement is safe and well tolerated, providing ongoing benefit. As oral GSH precursors both N-acetylcysteine95 and alpha-lipoic acid are appropriate. GSH is also a systemic antioxidant, and its ongoing repletion may help ameliorate Parkinson's-related damage in the heart, liver, muscles, and other organs.31 Systemic GSH status is also conserved by bolstering other antioxidant defenses. Especially noteworthy is high-dose vitamin C, which provides antioxidant reducing equivalents known to conserve GSH. 31. Kidd PM. Glutathione: systemic protectant against oxidative and free radical damage. Altern Med Rev 1997;2(3):155-176. 32. Perry TL, Godin DV, Hansen S. Parkinson's disease: a disorder due to nigral glutathione deficiency? Neurosci Lett 1982;33:305-310. 33. Jenner P. Oxidative mechanisms in nigral cell death in Parkinson's disease. Mov Disord 1998;13:S24-S34. 37. Youdim MBH, Ben-Schachar D, Riederer P. Is Parkinson's disease a progressive siderosis of substantia nigra resulting in iron and melanin induced neurodegeneration? Acta Neurol Scand 1989;126:47-54. More 2 cents when I get a chance to get back to the confuser if lightening doesn't scramble things again - Hope that this helps and as always my best to all ! Rob ----- Original Message ----- From: "Brightline" <[log in to unmask]> To: <[log in to unmask]> Sent: Tuesday, August 13, 2002 6:51 PM Subject: Re: Alpha Lipoic Acid? > Hi! Jann: > ALA is a very potent atioxidant and is recommended for PD. however, it > gives me very bad constipation. So I take a very small quantity once or > twice a week. > But, I am no sure about Acetyl-L-carnitine. I remember reading about > this in one of the NPF articles. I has been known to be converted into > nitrate and may be dangerous for health, if I remember right. > So study everything and take action with caution and complete knowledge > of each item. > Raj > [log in to unmask] > ***************************** > ----- Original Message ----- > From: "Jann Bell" <[log in to unmask]> > To: <[log in to unmask]> > Sent: Tuesday, August 13, 2002 7:08 PM > Subject: Re: Alpha Lipoic Acid? > > > > Such a coincident . . . I subscribe to an electronic newsletter called > > Longevity and their most recent issue addresses Alpha Lipoic acid. Of > > course, the newsletter is put out by a business ([log in to unmask]) and > > they would like for you to shop with them. However, I saw the Parkinson's > > post about ALA curiosity and have included this link (which was within the > > newsletter) I know our list has appropriate rules about bringing > commercial > > concerns into this forum, but this link looks like information, as opposed > > to a sales pitch. I haven't had time to go there myself today so I hope > this > > is helpful! > > > > the link > > More on Alpha Lipoic acid and Acetyl-L-Carnitine > > > <http://rs6.net/tn.jsp?t=cornlsn6.tvauesn6.yvsolsn6&p=http%3A%2F%2Fwww.young > > again.com%2Fnoname43.html> » > > > > CG Jann > > > > ---------------------------------------------------------------------- > > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > > In the body of the message put: signoff parkinsn > > > > > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn