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> I'm trying to decide if something I have been experiencing is a side effect of Permax (which I've > been on for just 5 weeks) or if my PD is progressing. Connie, my husband has had PD for 22 years. We have learned over the course of his disease that if his symptoms change suddenly after he has started or increased a medication, the medication is probably the cause. A case in point is our recent experience with Bactrim. Jamie had a devastating case of prostatitis that resulted in a 5 day hospital stay. Post hospitalization, he was placed on a 6 week course of Bactrim. We noticed that suddenly his dyskinesia increased. We had to cut back on his Sinemet and Mirapex to keep him functional. His neuro commented that, although Bactrim has not been known to interfere with PD drugs, he wouldn't be surprised at the possibility. He explained that anything that changes the pH of the gut will change the absorption of PD meds - thus causing side effects. Since you developed you symptoms after 5 weeks of Permax, one would immediately suspect the drug as being the problem. Talk with your neuro about it - call him on Monday. PD doesn't generally progress that quickly. ------ God bless Mary Ann (CG Jamie 62/22) ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn