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Brightline, You ask some very good questions. Hope answers will be forthcoming. The point of my "CoEnzyme Q10 Blues" was that from 4 different sources we received 4 different views on the study. I t appears the news reporters based their reports on Vitaline's press release. If they had read the actual jourrnal article in Archives of Neurology , they would have found that the researchers' conclusions were : "In our study, coenzyme Q10 treatment at high dosages was safe and well tolerated and reduced the worsening of PD, as reflected in the total UPDRS score. It would be premature to recommend the use of coenzyme Q10 for the treatment of PD. Our results need to be confirmed in a larger, phase 3 study, and the appropriate dosage and the magnitude of effect need to be better defined." Additionally the only mention in the journal article about Vitaline is that they donated the wafers for the study. I checked Vitaline's web site, where they offer a "special rate" to PD patients ---- "Each bottle of Vitaline CoQ10 contains 60 300mg chewable wafers, and is offered at $100 (compare to an expected retail price of $240 per bottle) One bottle is the equivalent of a one month supply of Vitaline CoQ10 at 600mg/day Two bottles is the equivalent of a one month supply of Vitaline CoQ10 at 1200mg/day" Another press release was isssued today by Emory University. One of the researchers -Dr. Watts put the trial results in perspective, sttating, "We are very encouraged with the results of this small trial, which consisted of 80 Parkinson's patients nationwide. However, a larger, multi-centered, controlled trial is still needed before this treatment can be recommended to patients with a high degree of certainty." ... "This is a very important study with positive results for Parkinson's patients," says Dr. Watts, a world-renowned Parkinson's disease researcher. "But we are not at the stage yet where we feel comfortable telling patients to go to their local health food store and purchase coenzyme Q10 as a treatment for the disease. Right now, we know this study shows vitamin-type therapy may slow the progression of movement and motor disabilities associated with the disease, but more studies are needed to determine the true effects of the compound. Emory will be involved in some larger coenzyme Q10 studies in the near future, in hopes of finding out these specific effects." The full press release - found by Murray Charters - is at EurekAlert http://www.eurekalert.org/pub_releases/2002-10/euhs-lss100902.php Also see the NY Times article he posted this morning about the lack of regulation for dietary supplements -"It's on the Label, But in the Tablet?" I think we should remain hopeful - a number of positive research results have been announced in the past week - we are surely getting closer. Linda On Tue, 15 Oct 2002 08:54:41 -0300 Brightline <[log in to unmask]> writes: > Hi! Everybody: > It is indeed a great news. But, as Linda reported, there seems > to be a > lot of hype and salesmanship go hand in hand in this story. > > Will somebody who really knows the physiology of CoE Q10 speak > out the > truth and enlighten all of us? > "VitaLine, the company that produces and donated the > COEnzyme Q > wafers used in the clinical trials.They state in their press release > that > only their product has been proven safe and effective. Other brands > may even > be harmful." > > 1. What is the truth here? CoEQ10 must be the same protein, no > matter by > what methhod or who manufactures it. Otherwise it will not be called > CoE > Q10! > 2. Given that product from other manufacturers have not been > tested, > does that really mean it won't be helpful or even be harmful? > 3. I suspect that if the product contains other CoE Qs such as > 1-9, the > liver converts them into CoE Q10. > 4. Vitaline CoE Q10 crosses the blood barrier successfully. > Does that > mean other manufacturer's CoEQ10 would not? Or we do not know if > they do? > If not, why not? Biochemically all the CoE Q10s should behave > identically. > If not, what is the real active ingredient in Vitaline's product? > 5. CoE Q10 has been tested only in the early stage patients of > PD. Does > this necessarily mean it won't be effectve in late stage PDPs? > Thank for your time. > Brightline > ************** > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: > mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn