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The following is a question I submitted to Ask the Doctor, and Dr. Lieberman's reply. question Dr. Lieberman: The final results of the study -- Placebo +11.99; 300mg +8.81; 600mg +10.82; 1200mg +6.69 are somewhat confusing to me. It would appear that the 600mg group progressed almost as much as the placebo group, and that the 300mg group did better than the 600mg group. Although the 1200mg group progressed the least, and therefore had the best outcome, the trend toward that result is statistically unusual. Can you comment? answer the comparison among the three groups involves a statistical method that compares the percent change from group to group using the number in each group and the probability the result could have been obtained by chance alone i am not a statistician and it is not a method with which I am well versed although the differences between 600 mg and 1200 mg do not seem great or profound, statistically they are the results with 1200 mg per day were not statistically significant to be so they would have to have a 95% probability they did not occur by chance alone they have a 92% probability they show a trend abe lieberman I don't think Dr. Lieberman answered my question, which is that the increases in dosage do not show a positive trend. It is true that the 1200mg group progressed the least. But it looks like the 300mg group did better than the 600mg group. It looks like the 600mg group did almost as badly as the placebo group. Something is wrong here. The study should typically show a positive trend from placebo to 1200mg. I am not a statistician, but my husband who has always worked with statistics also questions this. Can we talk about this? Ann Gibbons ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn