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I seem to do better when skipping my 4th daily dose if I remain fairly inactive but I find that true with this disease regardless. The more inactive I am usually helps with my meds. But every., one is different with this disease and Ihave had it for a very long time (25 years). My neuro know that I do this and he is agreeable. He told me that being stiffer or having dyskinesias is a choice that only I can make . carol gray ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn