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Nigel I am not a doctor but ??Dyskinesias is usually from drug overdosing and are seperate from tremors. Amantadine is what is used to control dyskinesias--I have used Entacapone(Comtan) here for over a year now. Entacapone has Extended Sinemet without increasing it's dosage on times for me an extra 45-90 minutes depending mostly on stress encountered during that time. My Sinemet 50/200 was wearing off in 3 hrs 20 minutes average time. Now that same dose with Entacapone lasts 4 hrs +. I am not sure from your description of meds that while it works in my case and is an excellent compliment with Sinemet, I have no experience using it with any of the drugs you listed, therefore cannot say if it will help your Madopar. No side effects encountered whatsoever from iEntacapone. Note: " Selegiline(eldepryl). Its main use is as an addition to treatment with levodopa, particularly for people who experience fluctuations in their mobility through the day. However over the past few years Selegiline, has shown that it may have a detrimental effect on the action of the heart." A study is being done to review its affects. Eldepryl belongs to a class of drugs known as MAO inhibitors. Amitriptyline- is contraindicated with any MAO inhibiters. " It should not be given concomitantly with a MAO inhibiting compound." Your Cabaser--A dopamine agonist is what is supposed to help Madopar be smooth throughout its cycle. I am wondering if the neuro gives you Entacapone what will he do with Cabaser and or Selegiline which are all designed to do the same " smooth out" but with a different method? Don 54/5 On Friday, November 29, 2002, at 02:18 AM, nigel harland wrote: > Hello all, > After several years of a reasonably managed medication > regime, the dreaded dyskenesia is making a slow but definite comeback. > I mentioned this to my Neuro this week, and he recommended that I > include Entacapone into my regime. Has anyone any experience of > Entacapone, good or bad, which they could share with me?? > My present meds are Madopar dispersible (187.5mg) 4 times a day, > Cabaser 4mg once a day, Amantadine 200mg once a day, Eldepryl 10mg > once a day, and finally Amitriptyline 50mg once a day. > > Thanks, > Nigel age 48, dx aged 35 ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn