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Good to hear from you. I was worried. I bet it was nice to have some one do the thanksgiving cooking for a change. Wow! In one night all the snow went away. Maybe we will get back to global warming again. I could use some of it. I dropped 30 lbs last year to get ready for old age, now I really feel the cold. Bought some winter underwear to compensate. I sleep with a sleeping bag, a nice warm one. Mother clued me in on that, holds body heat and moisture, much better quality sleep and the cats love it too. Dropped my grooming down to 2 a day, enjoying it a lot more exept the cold windy days. I have a good heater but have to keep turning it on and off. What is the back problem??? Gotta get going, a shaggy sheltie waiting for me in Rockland...thinking of you...Cliff ----- Original Message ----- From: "Kathleen Cochran" <[log in to unmask]> To: <[log in to unmask]> Sent: Wednesday, December 11, 2002 10:40 PM Subject: Mayo story: Permax and heart valve damage http://www.startribune.com/stories/1556/3523697.html Mayo: Parkinson's drug may damage heart valvesMaura Lerner Star Tribune Published Dec. 11, 2002 VALV11Mayo Clinic doctors say a drug for Parkinson's disease could damage people's heart valves in much the same way as the diet drug combination known as fen-phen. Mayo physicians discovered heart valve disease in three women taking pergolide, or Permax, a drug used to treat restless-leg syndrome as well as Parkinson's, according to a study released Tuesday. They said the valve damage was "strikingly similar" to that found in patients taking fen-phen (fenfluramine and phentermine), the diet pill combo that was pulled off the market in 1997 after Mayo brought to light the valve problems. "Given this possible association, we recommend that all patients taking pergolide undergo a thorough cardiovascular examination," the authors reported in December's Mayo Clinic Proceedings. The drug's manufacturer, Eli Lilly and Co., said it has received about a dozen reports of valve disease in the half-million patients who have taken Permax in the past 13 years. "We're talking about very rare occurrences," said Kindra Strupp, a corporate spokeswoman in Indianapolis. But she said the company is changing its warning label to add that risk, at the request made by the U.S. Food and Drug Administration several weeks ago, about the same time that the company learned of the Mayo Clinic's study. "There's not really a clear causal relationship," she said of the findings. But "we just know that, given the nature of the reports, that it seems prudent to make sure we include this in our label." The report, by cardiologist Dr. Raul Espinosa and colleagues, urged patients to stop taking pergolide if valve disease is detected. In an accompanying editorial, another cardiologist says the danger deserves notice. "Is the association with use of the drug real? Yes, until proved otherwise," wrote Dr. Shahbudin Rahimtoola, a professor at the University of Southern California at Los Angeles. "One could argue that this is a report of only three patients and that we should wait for more cases; however, try telling that to patients and families of those who subsequently develop [disease] that requires valve replacement." He said more research is needed to confirm the risk. The drug has been known to pose risks to people with irregular heartbeats. -- Maura Lerner is at [log in to unmask] ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn