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Good Morning All, My cyber sis Gail sent me the following excerpt.. Check this out... Characteristics and Treatment of Motor Complications in PD (Movement Disorders Congress 2002) Date: 11/24/2002 E-MOVE reports from the Seventh International Congress of Parkinson’s Disease and Movement Disorders, November 10- 14 in Miami, Florida. Poster (P), platform session (PL), and page numbers are from Movement Disorders 2002;17(suppl 5). 2. Intraintestinal infusion of L-dopa methyl ester in patients with advanced Parkinson's disease: A clinical and pharmacokinetic study F Stocchi, L Vacca, S Ruggieri, WC Olanow P218;S79 Continuous intraintestinal infusion of levodopa methyl ester increases on time and reduces dyskinesias, according to this prospective study. Six patients with advanced PD (H&Y stage 5) received levodopa methyl ester infusion pump into the intestine for 6 months. Off hours were reduced from 7.8 to 1.7 hours, on time without disabling dyskinesias increased from 0.3 to 9.4 hours, and the UPDRS dyskinesia score fell from 8.8 to 3.1. Pharmacokinetic analysis on 3 patients indicated a three-fold increase in the area under the curve and a four-fold increase in C-min. The authors suggest that "benefits associated with continuous levodopa infusion are related to maintaining the concentration above a minimal threshold, and that it may not be necessary to maintain the levodopa concentration at a constant level." http://www.wemove.org/emove/article.asp?ID=522 My comment? this is very impressive... who knew... hasn't hit the news, has it? Abstracts at scientific meetings often receive substantial attention in the high-profile media. ie; CoEnzyme Q10 For whatever reason, a substantial number of the studies seem to be ignored by the media.... Which begs the following question... why doesn't the foregoing rank up there with the coQ10 study? cheers .... murray * * * ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn