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On 12 Jan 2003 at 22:12, John Cottingham wrote: > Those Young Onset PDers wishing to participate in this study should contact > Amanda Singleton either at the email address or telephone number below. > > John Cottingham > > Scientists have just released news of a hereditary cause of Parkinson’s > disease (PD). Abnormalities in a gene called DJ-1 (PARK7) were found in > patients with PD from two different families; one from a small village in > the Netherlands, and another from a small village in Italy. These patients > had the hallmark PD signs (stiffness, slowing, tremor) but the symptoms > started earlier than (average age of 31), and progressed very slowly > (average duration was 18 years.) > > This finding will help scientists understand the biological chain of events > that lead to PD. Genes are like the body’s blueprints or building plans for > constructing healthy proteins, cells, and other materials. As with > blueprints for a building, if the blueprints for the human body have > mistakes (mutations), there is a good chance this will lead to structural > problems down the road. Understanding these gene mutations and predicting > the consequences of these structural problems gives scientists and doctors > the ability to intervene with drug therapies. > > Before scientists can begin developing interventions or treatments, there > are several questions to answer: > 1. How many patients with PD have abnormalities in DJ-1 (i.e., is it a > common or rare risk factor for PD) > 2. How many different DJ-1 abnormalities are there? > 3. Do DJ-1 abnormalities cause additional/different symptoms than > typical PD? > 4. How “potent” are the abnormalities (i.e., will everyone who inherits > a DJ-1 abnormality get PD) > > The Young Onset PD community can help us learn more about DJ-1 and about the > causes of PD by participating in our study at the NIH. The study involves > answering some questions by phone or mail questionnaire, and donating a > blood sample (about 6 tablespoons). Alternatively, we invite and encourage > individuals to come to NIH to participate in the study and for an evaluation > by a Parkinson’s disease specialist. There are no costs to you, whether you > participate by mail or travel to NIH (we will reimburse all transportation > and lodging charges.) > > If you are interested please contact: > Amanda Singleton > (301) 402-6231 > [log in to unmask] > Background Reading... NIH Press Release Nov 14, 1996 Scientists Locate Parkinson's Gene http://www.nih.gov/news/pr/nov96/nchgr-14.htm NIH Press Release June 26, 1997 NIH Researchers Find First Parkinson's Disease Gene http://www.nih.gov/news/pr/jun97/nhgri26a.htm Genetic Analysis of Parkinson's Disease Protocol Number: 97-HG-0078 The purposes of this study are to identify the gene or genes responsible for an inherited form of Parkinson's disease and learn more about how the disease develops. http://clinicalstudies.info.nih.gov/detail/A_1997-HG-0078.html Genetic Analysis of Parkinson's Disease http://clinicaltrials.gov/show/NCT00001640 Gene Analysis of Parkinson's Disease http://clinicaltrials.gov/show/NCT00001643 NIH Press Release Parkinson’s disease (PD) Newsletter: Find the genes and gene mutations that cause or contribute to neurological disease http://www.plwp.org/nih/parkinson%20newsletter.htm NIH Press Release Parkinson’s disease (PD) Newsletter: Scientists have just released news of a hereditary cause of Parkinson’s disease (PD). Abnormalities in a gene called DJ-1 (PARK7) were found in patients with PD from two different families; one from a small village in the Netherlands, and another from a small village in Italy. These patients had the hallmark PD signs (stiffness, slowing, tremor) but the symptoms started earlier than (average age of 31), and progressed very slowly (average duration was 18 years.) http://www.plwp.org/nih/nih_press_release.htm Mutations for Early Onset Parkinson's disease: DJ-1 (PARK7), a gene for early-onset parkinsonism http://www.beatrix.nl/nieuws_onderzoek.html Parkinson’s Disease Update Is Parkinson’s Disease Hereditary? http://www.parkinson.org/pdhereditary.htm Genes and Parkinsonism http://www.mayo.edu/fpd/in-the-news/molres.htm Researchers Plan to Use Genes to Treat Parkinson's https://www.parkinson.org/newsgenetherapy.htm Welcome to PubGene http://www.pubgene.com/ PubGene Gene Network Browser http://www.pubgene.uio.no/cgi- bin/hs/tools/Network/Browser.cgi?gene=PARK2 cheers ....... murray * * * Murray Charters <[log in to unmask]> http://www.geocities.com/murraycharters/ ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn