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HI, I tried comtan for about a year, 1999-2000. It was like a background drug as it didn't do any good by itself. After a few months a residual built up and this caused dyskinesia between 4-7 pm. I take 5 Sinemet 100 per day. Recently my Neuro took me off comtan and put me on an agonist Cabaser. I still get dyskinesia but it is not as bad as the comtan I have PD for over 30 years and I have had two sided DBS in STN As with all PD drugs , I let my neuro tell me how much to take during the start-up phase and then I cut it in half so I never get a bad reaction. It takes about twice as long to get the benefit but it causes less stress on the brain . Cabaser took 18 days to receive any benefit GO VERY SLOW IF NOT SLOWER Barry ----- Original Message ----- From: "Gail Vass" <[log in to unmask]> To: <[log in to unmask]> Sent: Friday, February 14, 2003 8:29 AM Subject: Starting Comtan > I went to a Parkinson Support Meeting last night > and heard a lecture by Movement Disorder Specialist > Dr Linda Sigmund. She gave an excellent lecture > about "The A-B-C's of Parkinson's Disease". > > She gives this lecture annually but updates it each > year with the latest news and shares some of her > experience in the field. > > Last night when she was fielding questions from the > audience she mentioned that she does NOT start her > patients on a full dose of Comtan 200 mg when she > begins the therapy. > > She went on to say that many patients were unsuccessful > beginning with a full dose of Comtan, so that she begins > her patients on HALF [ 1/2 of the tablet ] of the recommended > dose for * a full week * before increasing their dose up to one > full tablet with each Sinemet. > > Now of course, this has to be approved by your own physician > but I felt this was important information to pass on as some > Parkies have "tried" Comtan and had "problems" taking the > medication and maybe they found what her own experience > was, that some patients can't start with the whole pill all at once. > > I felt this was valuable information to pass on because those who > are able to take Comtan are often able to take less Sinemet. > > NPF's Dr Abraham Lieberman MD, Medical Director has posted > some info on Comtan: > http://www.parkinson.org/texthtms/tcomtan2.htm > > Gail Vass > > ---------------------------------------------------------------------- > To sign-off Parkinsn send a message to: mailto:[log in to unmask] > In the body of the message put: signoff parkinsn > ---------------------------------------------------------------------- To sign-off Parkinsn send a message to: mailto:[log in to unmask] In the body of the message put: signoff parkinsn